Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-independent functions of DAXX.

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Autores principales:	Dominik Hoelper, Hongda Huang, Aayushi Y. Jain, Dinshaw J. Patel, Peter W. Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0eb14fc947d44504ad5c2c9805c2cc49
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spelling	oai:doaj.org-article:0eb14fc947d44504ad5c2c9805c2cc492021-12-02T17:06:17ZStructural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX10.1038/s41467-017-01206-y2041-1723https://doaj.org/article/0eb14fc947d44504ad5c2c9805c2cc492017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01206-yhttps://doaj.org/toc/2041-1723The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-independent functions of DAXX.Dominik HoelperHongda HuangAayushi Y. JainDinshaw J. PatelPeter W. LewisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dominik Hoelper Hongda Huang Aayushi Y. Jain Dinshaw J. Patel Peter W. Lewis Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
description	The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-independent functions of DAXX.
format	article
author	Dominik Hoelper Hongda Huang Aayushi Y. Jain Dinshaw J. Patel Peter W. Lewis
author_facet	Dominik Hoelper Hongda Huang Aayushi Y. Jain Dinshaw J. Patel Peter W. Lewis
author_sort	Dominik Hoelper
title	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
title_short	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
title_full	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
title_fullStr	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
title_full_unstemmed	Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX
title_sort	structural and mechanistic insights into atrx-dependent and -independent functions of the histone chaperone daxx
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0eb14fc947d44504ad5c2c9805c2cc49
work_keys_str_mv	AT dominikhoelper structuralandmechanisticinsightsintoatrxdependentandindependentfunctionsofthehistonechaperonedaxx AT hongdahuang structuralandmechanisticinsightsintoatrxdependentandindependentfunctionsofthehistonechaperonedaxx AT aayushiyjain structuralandmechanisticinsightsintoatrxdependentandindependentfunctionsofthehistonechaperonedaxx AT dinshawjpatel structuralandmechanisticinsightsintoatrxdependentandindependentfunctionsofthehistonechaperonedaxx AT peterwlewis structuralandmechanisticinsightsintoatrxdependentandindependentfunctionsofthehistonechaperonedaxx
_version_	1718381658042793984

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

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