Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

The ATRX-DAXX histone chaperone complex incorporates H3.3 in heterochromatin in a replication-independent manner. Here, the authors present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX, and characterize ATRX-dependent and-independent functions of DAXX.

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Detalles Bibliográficos
Autores principales: Dominik Hoelper, Hongda Huang, Aayushi Y. Jain, Dinshaw J. Patel, Peter W. Lewis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/0eb14fc947d44504ad5c2c9805c2cc49
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