Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can prime DCs for anti-viral immunity via the cGAS/STI...

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Autores principales:	Daniel Torralba, Francesc Baixauli, Carolina Villarroya-Beltri, Irene Fernández-Delgado, Ana Latorre-Pellicer, Rebeca Acín-Pérez, Noa B Martín-Cófreces, Ángel Luis Jaso-Tamame, Salvador Iborra, Inmaculada Jorge, Gloria González-Aseguinolaza, Johan Garaude, Miguel Vicente-Manzanares, José Antonio Enríquez, María Mittelbrunn, Francisco Sánchez-Madrid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0eb2c72dba52481d83ba1541aba39d30
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:0eb2c72dba52481d83ba1541aba39d302021-12-02T15:34:01ZPriming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts10.1038/s41467-018-05077-92041-1723https://doaj.org/article/0eb2c72dba52481d83ba1541aba39d302018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05077-9https://doaj.org/toc/2041-1723T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can prime DCs for anti-viral immunity via the cGAS/STING DNA sensing pathways.Daniel TorralbaFrancesc BaixauliCarolina Villarroya-BeltriIrene Fernández-DelgadoAna Latorre-PellicerRebeca Acín-PérezNoa B Martín-CófrecesÁngel Luis Jaso-TamameSalvador IborraInmaculada JorgeGloria González-AseguinolazaJohan GaraudeMiguel Vicente-ManzanaresJosé Antonio EnríquezMaría MittelbrunnFrancisco Sánchez-MadridNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Torralba Francesc Baixauli Carolina Villarroya-Beltri Irene Fernández-Delgado Ana Latorre-Pellicer Rebeca Acín-Pérez Noa B Martín-Cófreces Ángel Luis Jaso-Tamame Salvador Iborra Inmaculada Jorge Gloria González-Aseguinolaza Johan Garaude Miguel Vicente-Manzanares José Antonio Enríquez María Mittelbrunn Francisco Sánchez-Madrid Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
description	T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can prime DCs for anti-viral immunity via the cGAS/STING DNA sensing pathways.
format	article
author	Daniel Torralba Francesc Baixauli Carolina Villarroya-Beltri Irene Fernández-Delgado Ana Latorre-Pellicer Rebeca Acín-Pérez Noa B Martín-Cófreces Ángel Luis Jaso-Tamame Salvador Iborra Inmaculada Jorge Gloria González-Aseguinolaza Johan Garaude Miguel Vicente-Manzanares José Antonio Enríquez María Mittelbrunn Francisco Sánchez-Madrid
author_facet	Daniel Torralba Francesc Baixauli Carolina Villarroya-Beltri Irene Fernández-Delgado Ana Latorre-Pellicer Rebeca Acín-Pérez Noa B Martín-Cófreces Ángel Luis Jaso-Tamame Salvador Iborra Inmaculada Jorge Gloria González-Aseguinolaza Johan Garaude Miguel Vicente-Manzanares José Antonio Enríquez María Mittelbrunn Francisco Sánchez-Madrid
author_sort	Daniel Torralba
title	Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
title_short	Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
title_full	Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
title_fullStr	Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
title_full_unstemmed	Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
title_sort	priming of dendritic cells by dna-containing extracellular vesicles from activated t cells through antigen-driven contacts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0eb2c72dba52481d83ba1541aba39d30
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Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

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