UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Abstract Hypoxia-inducible factor 1 (HIF-1) has been recognized as an important mediator of the reprogramming of carbohydrate metabolic pathways from oxidative phosphorylation to accelerated glycolysis. Although this reprogramming has been associated with the antioxidant and radioresistant propertie...

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Autores principales: Ryota Nakashima, Yoko Goto, Sho Koyasu, Minoru Kobayashi, Akiyo Morinibu, Michio Yoshimura, Masahiro Hiraoka, Ester M. Hammond, Hiroshi Harada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0eb813fe8b2c4d88992eb98d2a5ae043
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