SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.

The protein deacetylase SIRT1 has been implicated in the regulation of a large number of cellular processes that are thought to be required for cancer initiation and progression. There are conflicting data that make it unclear whether Sirt1 functions as an oncogene or tumor suppressor. To assess the...

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Autores principales:	Katherine V Clark-Knowles, Danielle Dewar-Darch, Karen E Jardine, Michael W McBurney
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0eba3d34cfb346f3beb5d450b322581b
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spelling	oai:doaj.org-article:0eba3d34cfb346f3beb5d450b322581b2021-11-18T08:45:07ZSIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.1932-620310.1371/journal.pone.0082106https://doaj.org/article/0eba3d34cfb346f3beb5d450b322581b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278473/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The protein deacetylase SIRT1 has been implicated in the regulation of a large number of cellular processes that are thought to be required for cancer initiation and progression. There are conflicting data that make it unclear whether Sirt1 functions as an oncogene or tumor suppressor. To assess the effect of SIRT1 on the emergence and progression of mammary tumors, we crossed mice that harbor a point mutation that abolishes SIRT1 catalytic activity with mice carrying the polyoma middle T transgene driven by the murine mammary tumor virus promoter (MMTV-PyMT). The absence of SIRT1 catalytic activity neither accelerated nor blocked the formation of tumors and metastases in this model. There was a lag in tumor latency that modestly extended survival in Sirt1 mutant mice that we attribute to a delay in mammary gland development and not to a direct effect of SIRT1 on carcinogenesis. These results are consistent with previous evidence suggesting that Sirt1 is not a tumor promoter or a tumor suppressor.Katherine V Clark-KnowlesDanielle Dewar-DarchKaren E JardineMichael W McBurneyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e82106 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katherine V Clark-Knowles Danielle Dewar-Darch Karen E Jardine Michael W McBurney SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
description	The protein deacetylase SIRT1 has been implicated in the regulation of a large number of cellular processes that are thought to be required for cancer initiation and progression. There are conflicting data that make it unclear whether Sirt1 functions as an oncogene or tumor suppressor. To assess the effect of SIRT1 on the emergence and progression of mammary tumors, we crossed mice that harbor a point mutation that abolishes SIRT1 catalytic activity with mice carrying the polyoma middle T transgene driven by the murine mammary tumor virus promoter (MMTV-PyMT). The absence of SIRT1 catalytic activity neither accelerated nor blocked the formation of tumors and metastases in this model. There was a lag in tumor latency that modestly extended survival in Sirt1 mutant mice that we attribute to a delay in mammary gland development and not to a direct effect of SIRT1 on carcinogenesis. These results are consistent with previous evidence suggesting that Sirt1 is not a tumor promoter or a tumor suppressor.
format	article
author	Katherine V Clark-Knowles Danielle Dewar-Darch Karen E Jardine Michael W McBurney
author_facet	Katherine V Clark-Knowles Danielle Dewar-Darch Karen E Jardine Michael W McBurney
author_sort	Katherine V Clark-Knowles
title	SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
title_short	SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
title_full	SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
title_fullStr	SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
title_full_unstemmed	SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
title_sort	sirt1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0eba3d34cfb346f3beb5d450b322581b
work_keys_str_mv	AT katherinevclarkknowles sirt1catalyticactivityhaslittleeffectontumorformationandmetastasesinamousemodelofbreastcancer AT danielledewardarch sirt1catalyticactivityhaslittleeffectontumorformationandmetastasesinamousemodelofbreastcancer AT karenejardine sirt1catalyticactivityhaslittleeffectontumorformationandmetastasesinamousemodelofbreastcancer AT michaelwmcburney sirt1catalyticactivityhaslittleeffectontumorformationandmetastasesinamousemodelofbreastcancer
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SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer.

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