ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.

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Detalles Bibliográficos
Autores principales:	Juanjuan Ou, Yuan Peng, Weiwen Yang, Yue Zhang, Jie Hao, Fu Li, Yanrong Chen, Yang Zhao, Xiong Xie, Shuang Wu, Lin Zha, Xi Luo, Ganfeng Xie, Liting Wang, Wei Sun, Qi Zhou, Jianjun Li, Houjie Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ebbd1f157fd4438812c694b8a00a589
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spelling	oai:doaj.org-article:0ebbd1f157fd4438812c694b8a00a5892021-12-02T14:38:59ZABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield10.1038/s41467-019-08902-x2041-1723https://doaj.org/article/0ebbd1f157fd4438812c694b8a00a5892019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08902-xhttps://doaj.org/toc/2041-1723The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.Juanjuan OuYuan PengWeiwen YangYue ZhangJie HaoFu LiYanrong ChenYang ZhaoXiong XieShuang WuLin ZhaXi LuoGanfeng XieLiting WangWei SunQi ZhouJianjun LiHoujie LiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juanjuan Ou Yuan Peng Weiwen Yang Yue Zhang Jie Hao Fu Li Yanrong Chen Yang Zhao Xiong Xie Shuang Wu Lin Zha Xi Luo Ganfeng Xie Liting Wang Wei Sun Qi Zhou Jianjun Li Houjie Liang ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
description	The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.
format	article
author	Juanjuan Ou Yuan Peng Weiwen Yang Yue Zhang Jie Hao Fu Li Yanrong Chen Yang Zhao Xiong Xie Shuang Wu Lin Zha Xi Luo Ganfeng Xie Liting Wang Wei Sun Qi Zhou Jianjun Li Houjie Liang
author_facet	Juanjuan Ou Yuan Peng Weiwen Yang Yue Zhang Jie Hao Fu Li Yanrong Chen Yang Zhao Xiong Xie Shuang Wu Lin Zha Xi Luo Ganfeng Xie Liting Wang Wei Sun Qi Zhou Jianjun Li Houjie Liang
author_sort	Juanjuan Ou
title	ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
title_short	ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
title_full	ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
title_fullStr	ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
title_full_unstemmed	ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
title_sort	abhd5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0ebbd1f157fd4438812c694b8a00a589
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ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

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