Novel dipeptide nanoparticles for effective curcumin delivery

Shadab Alam,* Jiban J Panda,* Virander S Chauhan International Centre for Genetic Engineering and Biotechnology, New Delhi, India*Both authors contributed equally to this workBackground: Curcumin, the principal curcuminoid of the popular Indian spice turmeric, has a wide spectrum of pharmaceutical p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alam S, Panda JJ, Chauhan VS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0ebf7466030d483aa32570f38e3fb50c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ebf7466030d483aa32570f38e3fb50c
record_format	dspace
spelling	oai:doaj.org-article:0ebf7466030d483aa32570f38e3fb50c2021-12-02T00:40:23ZNovel dipeptide nanoparticles for effective curcumin delivery1176-91141178-2013https://doaj.org/article/0ebf7466030d483aa32570f38e3fb50c2012-08-01T00:00:00Zhttp://www.dovepress.com/novel-dipeptide-nanoparticles-for-effective-curcumin-delivery-a10612https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Shadab Alam,* Jiban J Panda,* Virander S Chauhan International Centre for Genetic Engineering and Biotechnology, New Delhi, India*Both authors contributed equally to this workBackground: Curcumin, the principal curcuminoid of the popular Indian spice turmeric, has a wide spectrum of pharmaceutical properties such as antitumor, antioxidant, antiamyloid, and anti-inflammatory activity. However, poor aqueous solubility and low bioavailability of curcumin is a major challenge in its development as a useful drug. To enhance the aqueous solubility and bioavailability of curcumin, attempts have been made to encapsulate it in liposomes, polymeric nanoparticles (NPs), lipid-based NPs, biodegradable microspheres, cyclodextrin, and hydrogels.Methods: In this work, we attempted to entrap curcumin in novel self-assembled dipeptide NPs containing a nonprotein amino acid, &alpha;,&beta;-dehydrophenylalanine, and investigated the biological activity of dipeptide-curcumin NPs in cancer models both in vitro and in vivo.Results: Of the several dehydrodipeptides tested, methionine-dehydrophenylalanine was the most suitable one for loading and release of curcumin. Loading of curcumin in the dipeptide NPs increased its solubility, improved cellular availability, enhanced its toxicity towards different cancerous cell lines, and enhanced curcumin&rsquo;s efficacy towards inhibiting tumor growth in Balb/c mice bearing a B6F10 melanoma tumor.Conclusion: These novel, highly biocompatible, and easy to construct dipeptide NPs with a capacity to load and release curcumin in a sustained manner significantly improved curcumin&rsquo;s cellular uptake without altering its anticancer or other therapeutic properties. Curcumin-dipeptide NPs also showed improved in vitro and in vivo chemotherapeutic efficacy compared to curcumin alone. Such dipeptide-NPs may also improve the delivery of other potent hydrophobic drug molecules that show poor cellular uptake, bioavailability, and efficacy.Keywords: anticancer, curcumin, dipeptide, hydrophobic, nanoparticle, self-assemblyAlam SPanda JJChauhan VSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4207-4222 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Alam S Panda JJ Chauhan VS Novel dipeptide nanoparticles for effective curcumin delivery
description	Shadab Alam,* Jiban J Panda,* Virander S Chauhan International Centre for Genetic Engineering and Biotechnology, New Delhi, India*Both authors contributed equally to this workBackground: Curcumin, the principal curcuminoid of the popular Indian spice turmeric, has a wide spectrum of pharmaceutical properties such as antitumor, antioxidant, antiamyloid, and anti-inflammatory activity. However, poor aqueous solubility and low bioavailability of curcumin is a major challenge in its development as a useful drug. To enhance the aqueous solubility and bioavailability of curcumin, attempts have been made to encapsulate it in liposomes, polymeric nanoparticles (NPs), lipid-based NPs, biodegradable microspheres, cyclodextrin, and hydrogels.Methods: In this work, we attempted to entrap curcumin in novel self-assembled dipeptide NPs containing a nonprotein amino acid, &alpha;,&beta;-dehydrophenylalanine, and investigated the biological activity of dipeptide-curcumin NPs in cancer models both in vitro and in vivo.Results: Of the several dehydrodipeptides tested, methionine-dehydrophenylalanine was the most suitable one for loading and release of curcumin. Loading of curcumin in the dipeptide NPs increased its solubility, improved cellular availability, enhanced its toxicity towards different cancerous cell lines, and enhanced curcumin&rsquo;s efficacy towards inhibiting tumor growth in Balb/c mice bearing a B6F10 melanoma tumor.Conclusion: These novel, highly biocompatible, and easy to construct dipeptide NPs with a capacity to load and release curcumin in a sustained manner significantly improved curcumin&rsquo;s cellular uptake without altering its anticancer or other therapeutic properties. Curcumin-dipeptide NPs also showed improved in vitro and in vivo chemotherapeutic efficacy compared to curcumin alone. Such dipeptide-NPs may also improve the delivery of other potent hydrophobic drug molecules that show poor cellular uptake, bioavailability, and efficacy.Keywords: anticancer, curcumin, dipeptide, hydrophobic, nanoparticle, self-assembly
format	article
author	Alam S Panda JJ Chauhan VS
author_facet	Alam S Panda JJ Chauhan VS
author_sort	Alam S
title	Novel dipeptide nanoparticles for effective curcumin delivery
title_short	Novel dipeptide nanoparticles for effective curcumin delivery
title_full	Novel dipeptide nanoparticles for effective curcumin delivery
title_fullStr	Novel dipeptide nanoparticles for effective curcumin delivery
title_full_unstemmed	Novel dipeptide nanoparticles for effective curcumin delivery
title_sort	novel dipeptide nanoparticles for effective curcumin delivery
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/0ebf7466030d483aa32570f38e3fb50c
work_keys_str_mv	AT alams noveldipeptidenanoparticlesforeffectivecurcumindelivery AT pandajj noveldipeptidenanoparticlesforeffectivecurcumindelivery AT chauhanvs noveldipeptidenanoparticlesforeffectivecurcumindelivery
_version_	1718403539283214336

Novel dipeptide nanoparticles for effective curcumin delivery

Ejemplares similares