Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study

Abstract To investigate the association of familial history (FH) of diabetes with the glycaemic control status of patients with type 2 diabetes (T2D), a cross-sectional study using stratified cluster sampling was conducted with 20,340 diabetic patients in Jiangsu, China. In total, 21.3% of the subje...

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Autores principales:	Ming Wu, Jinbo Wen, Yu Qin, Hailong Zhao, Xiaoqun Pan, Jian Su, Wencong Du, Enchun Pan, Qin Zhang, Ning Zhang, Hongyan Sheng, Chunlan Liu, Chong Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ec28799b82942d896455eff91ca48f1
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spelling	oai:doaj.org-article:0ec28799b82942d896455eff91ca48f12021-12-02T11:40:44ZFamilial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study10.1038/s41598-017-01527-42045-2322https://doaj.org/article/0ec28799b82942d896455eff91ca48f12017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01527-4https://doaj.org/toc/2045-2322Abstract To investigate the association of familial history (FH) of diabetes with the glycaemic control status of patients with type 2 diabetes (T2D), a cross-sectional study using stratified cluster sampling was conducted with 20,340 diabetic patients in Jiangsu, China. In total, 21.3% of the subjects reported a FH of diabetes. Patients with a FH of diabetes showed a higher risk of poor glycaemic control (59.7%) than those without a diabetic FH (49.8%), with an odds ratio (OR) of 1.366 (P < 0.001). Glycaemic control status did not significantly differ between the T2D patients with parental FH and those with sibling FH. Compared with patients with paternal FH, patients with maternal FH had a higher risk of poor glycaemic control (OR = 1.611, P = 0.013). Stratified analyses showed that a FH of diabetes was significantly associated with poor glycaemic control among T2D patients with a low education level (P < 0.05). In the <60 years old, overweight, and low level of physical activity groups, patients with a maternal history of diabetes showed a higher risk of poor glycaemic control than those without a FH (P < 0.05). In conclusion, FH of diabetes, especially a maternal history, had an independently adverse effect on the glycaemic control of T2D patients.Ming WuJinbo WenYu QinHailong ZhaoXiaoqun PanJian SuWencong DuEnchun PanQin ZhangNing ZhangHongyan ShengChunlan LiuChong ShenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming Wu Jinbo Wen Yu Qin Hailong Zhao Xiaoqun Pan Jian Su Wencong Du Enchun Pan Qin Zhang Ning Zhang Hongyan Sheng Chunlan Liu Chong Shen Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study
description	Abstract To investigate the association of familial history (FH) of diabetes with the glycaemic control status of patients with type 2 diabetes (T2D), a cross-sectional study using stratified cluster sampling was conducted with 20,340 diabetic patients in Jiangsu, China. In total, 21.3% of the subjects reported a FH of diabetes. Patients with a FH of diabetes showed a higher risk of poor glycaemic control (59.7%) than those without a diabetic FH (49.8%), with an odds ratio (OR) of 1.366 (P < 0.001). Glycaemic control status did not significantly differ between the T2D patients with parental FH and those with sibling FH. Compared with patients with paternal FH, patients with maternal FH had a higher risk of poor glycaemic control (OR = 1.611, P = 0.013). Stratified analyses showed that a FH of diabetes was significantly associated with poor glycaemic control among T2D patients with a low education level (P < 0.05). In the <60 years old, overweight, and low level of physical activity groups, patients with a maternal history of diabetes showed a higher risk of poor glycaemic control than those without a FH (P < 0.05). In conclusion, FH of diabetes, especially a maternal history, had an independently adverse effect on the glycaemic control of T2D patients.
format	article
author	Ming Wu Jinbo Wen Yu Qin Hailong Zhao Xiaoqun Pan Jian Su Wencong Du Enchun Pan Qin Zhang Ning Zhang Hongyan Sheng Chunlan Liu Chong Shen
author_facet	Ming Wu Jinbo Wen Yu Qin Hailong Zhao Xiaoqun Pan Jian Su Wencong Du Enchun Pan Qin Zhang Ning Zhang Hongyan Sheng Chunlan Liu Chong Shen
author_sort	Ming Wu
title	Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study
title_short	Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study
title_full	Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study
title_fullStr	Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study
title_full_unstemmed	Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study
title_sort	familial history of diabetes is associated with poor glycaemic control in type 2 diabetics: a cross-sectional study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0ec28799b82942d896455eff91ca48f1
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Familial History of Diabetes is Associated with Poor Glycaemic Control in Type 2 Diabetics: A Cross-sectional Study

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