Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

The dynamics of chromatin and transcriptional changes underlying Huntington’s disease remain poorly understood. Here the authors use a Huntington’s mouse model to profile the striatal chromatin landscape, finding that the Huntington’s mutation accelerates age-dependent epigenetic and transcriptional...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rafael Alcalá-Vida, Jonathan Seguin, Caroline Lotz, Anne M. Molitor, Ibai Irastorza-Azcarate, Ali Awada, Nezih Karasu, Aurélie Bombardier, Brigitte Cosquer, Jose Luis Gomez Skarmeta, Jean-Christophe Cassel, Anne-Laurence Boutillier, Thomas Sexton, Karine Merienne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ec358ea614448bdbbaf8af73cea827a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ec358ea614448bdbbaf8af73cea827a
record_format	dspace
spelling	oai:doaj.org-article:0ec358ea614448bdbbaf8af73cea827a2021-12-02T14:12:04ZAge-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice10.1038/s41467-020-20605-22041-1723https://doaj.org/article/0ec358ea614448bdbbaf8af73cea827a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20605-2https://doaj.org/toc/2041-1723The dynamics of chromatin and transcriptional changes underlying Huntington’s disease remain poorly understood. Here the authors use a Huntington’s mouse model to profile the striatal chromatin landscape, finding that the Huntington’s mutation accelerates age-dependent epigenetic and transcriptional changes, and locally affects 3D chromatin organization.Rafael Alcalá-VidaJonathan SeguinCaroline LotzAnne M. MolitorIbai Irastorza-AzcarateAli AwadaNezih KarasuAurélie BombardierBrigitte CosquerJose Luis Gomez SkarmetaJean-Christophe CasselAnne-Laurence BoutillierThomas SextonKarine MerienneNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael Alcalá-Vida Jonathan Seguin Caroline Lotz Anne M. Molitor Ibai Irastorza-Azcarate Ali Awada Nezih Karasu Aurélie Bombardier Brigitte Cosquer Jose Luis Gomez Skarmeta Jean-Christophe Cassel Anne-Laurence Boutillier Thomas Sexton Karine Merienne Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
description	The dynamics of chromatin and transcriptional changes underlying Huntington’s disease remain poorly understood. Here the authors use a Huntington’s mouse model to profile the striatal chromatin landscape, finding that the Huntington’s mutation accelerates age-dependent epigenetic and transcriptional changes, and locally affects 3D chromatin organization.
format	article
author	Rafael Alcalá-Vida Jonathan Seguin Caroline Lotz Anne M. Molitor Ibai Irastorza-Azcarate Ali Awada Nezih Karasu Aurélie Bombardier Brigitte Cosquer Jose Luis Gomez Skarmeta Jean-Christophe Cassel Anne-Laurence Boutillier Thomas Sexton Karine Merienne
author_facet	Rafael Alcalá-Vida Jonathan Seguin Caroline Lotz Anne M. Molitor Ibai Irastorza-Azcarate Ali Awada Nezih Karasu Aurélie Bombardier Brigitte Cosquer Jose Luis Gomez Skarmeta Jean-Christophe Cassel Anne-Laurence Boutillier Thomas Sexton Karine Merienne
author_sort	Rafael Alcalá-Vida
title	Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
title_short	Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
title_full	Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
title_fullStr	Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
title_full_unstemmed	Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
title_sort	age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in huntington’s disease mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0ec358ea614448bdbbaf8af73cea827a
work_keys_str_mv	AT rafaelalcalavida agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT jonathanseguin agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT carolinelotz agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT annemmolitor agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT ibaiirastorzaazcarate agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT aliawada agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT nezihkarasu agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT aureliebombardier agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT brigittecosquer agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT joseluisgomezskarmeta agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT jeanchristophecassel agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT annelaurenceboutillier agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT thomassexton agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice AT karinemerienne agerelatedanddiseaselocusspecificmechanismscontributetoearlyremodellingofchromatinstructureinhuntingtonsdiseasemice
_version_	1718391828126892032

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

Ejemplares similares