Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program

Zain Hussain Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USACorrespondence: Zain Hussain Email zain.hussain@ttuhsc.eduBackground: Retinoblastoma is an intraocular cancer with potentially severe clinical consequences if left untreated. Diagnostic and...

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Autor principal:	Hussain Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	retinoblastoma survival laterality Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0ec3e0fedcf44378868d85ef7add237e
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spelling	oai:doaj.org-article:0ec3e0fedcf44378868d85ef7add237e2021-12-02T14:20:37ZImpact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program1177-5483https://doaj.org/article/0ec3e0fedcf44378868d85ef7add237e2021-03-01T00:00:00Zhttps://www.dovepress.com/impact-of-laterality-on-cumulative-survival-in-patients-diagnosed-with-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Zain Hussain Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USACorrespondence: Zain Hussain Email zain.hussain@ttuhsc.eduBackground: Retinoblastoma is an intraocular cancer with potentially severe clinical consequences if left untreated. Diagnostic and clinical management guidelines are strictly dependent on nature of laterality. This analysis aims to characterize the influence of laterality on survival in patients diagnosed with retinoblastoma.Methods: This retrospective cohort analysis utilized the Surveillance, Epidemiology, and End Results (SEER) program for population-based clinical data from 1975 to 2016, a period of 41 years. Univariable and multivariable Cox regression assessed survival with laterality as the primary independent predictor of mortality. Adjustment for demographical and clinical variables was performed.Results: N = 1925 patients with a valid cause of death classification. Mean±SD age was 2.35± 2.020 years (range 0– 74). At the time of diagnosis, 819 (42.1%) patients were between 0 and 1 year of age, 469 (24.1%) patients were between 1 and 2 years, 350 (18.0%) patients were between 2 and 3 years, 147 (7.6%) patients were between 3 and 4 years, and 68 (3.5%) patients were between 4 and 5 years of age. The hazard of univariable cause-specific death is 55.6% and 52.9% lower for retinoblastoma patients with left-sided origin and right-sided origin as compared to patients with bilateral origin, respectively (HR = 0.444, CI 0.247– 0.800, p = 0.007; HR = 0.471, CI 0.267– 0.832, p = 0.009). After adjusting for confounding variables, the hazard of other-cause death for retinoblastoma patients is significantly less for left-sided origin (HR = 0.364, CI 0.140– 0.946, p = 0.038) and right-sided origin (HR = 0.190, CI 0.066– 0.549, p = 0.002) as compared to patients with retinoblastomas of bilateral origin.Conclusion: Prognostication of survival is significantly influenced by the nature of laterality in retinoblastoma. Unilateral retinoblastomas showcase increased promise for long-term cause-specific and other-cause survival compared to cases of retinoblastoma arising from bilateral origin.Keywords: retinoblastoma, survival, lateralityHussain ZDove Medical PressarticleretinoblastomasurvivallateralityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 991-1001 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinoblastoma survival laterality Ophthalmology RE1-994
spellingShingle	retinoblastoma survival laterality Ophthalmology RE1-994 Hussain Z Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program
description	Zain Hussain Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USACorrespondence: Zain Hussain Email zain.hussain@ttuhsc.eduBackground: Retinoblastoma is an intraocular cancer with potentially severe clinical consequences if left untreated. Diagnostic and clinical management guidelines are strictly dependent on nature of laterality. This analysis aims to characterize the influence of laterality on survival in patients diagnosed with retinoblastoma.Methods: This retrospective cohort analysis utilized the Surveillance, Epidemiology, and End Results (SEER) program for population-based clinical data from 1975 to 2016, a period of 41 years. Univariable and multivariable Cox regression assessed survival with laterality as the primary independent predictor of mortality. Adjustment for demographical and clinical variables was performed.Results: N = 1925 patients with a valid cause of death classification. Mean±SD age was 2.35± 2.020 years (range 0– 74). At the time of diagnosis, 819 (42.1%) patients were between 0 and 1 year of age, 469 (24.1%) patients were between 1 and 2 years, 350 (18.0%) patients were between 2 and 3 years, 147 (7.6%) patients were between 3 and 4 years, and 68 (3.5%) patients were between 4 and 5 years of age. The hazard of univariable cause-specific death is 55.6% and 52.9% lower for retinoblastoma patients with left-sided origin and right-sided origin as compared to patients with bilateral origin, respectively (HR = 0.444, CI 0.247– 0.800, p = 0.007; HR = 0.471, CI 0.267– 0.832, p = 0.009). After adjusting for confounding variables, the hazard of other-cause death for retinoblastoma patients is significantly less for left-sided origin (HR = 0.364, CI 0.140– 0.946, p = 0.038) and right-sided origin (HR = 0.190, CI 0.066– 0.549, p = 0.002) as compared to patients with retinoblastomas of bilateral origin.Conclusion: Prognostication of survival is significantly influenced by the nature of laterality in retinoblastoma. Unilateral retinoblastomas showcase increased promise for long-term cause-specific and other-cause survival compared to cases of retinoblastoma arising from bilateral origin.Keywords: retinoblastoma, survival, laterality
format	article
author	Hussain Z
author_facet	Hussain Z
author_sort	Hussain Z
title	Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program
title_short	Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program
title_full	Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program
title_fullStr	Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program
title_full_unstemmed	Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program
title_sort	impact of laterality on cumulative survival in patients diagnosed with retinoblastoma: a retrospective cohort analysis of 1925 cases in the surveillance, epidemiology, and end results (seer) program
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0ec3e0fedcf44378868d85ef7add237e
work_keys_str_mv	AT hussainz impactoflateralityoncumulativesurvivalinpatientsdiagnosedwithretinoblastomaaretrospectivecohortanalysisof1925casesinthesurveillanceepidemiologyandendresultsseerprogram
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Impact of Laterality on Cumulative Survival in Patients Diagnosed with Retinoblastoma: A Retrospective Cohort Analysis of 1925 Cases in the Surveillance, Epidemiology, and End Results (SEER) Program

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