Enhancing KCC2 function counteracts morphine-induced hyperalgesia

Enhancing KCC2 function counteracts morphine-induced hyperalgesia

Abstract Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl− extruder KCC2 in the superficial dorsal horn (SDH) of the...

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Autores principales: Francesco Ferrini, Louis-Etienne Lorenzo, Antoine G. Godin, Miorie Le Quang, Yves De Koninck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0eca9d636d3343e999ceb6e781d6238c
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