Exosomes as Intercellular Messengers in Hypertension

People living with hypertension have a higher risk of developing heart diseases, and hypertension remains a top cause of mortality. In hypertension, some detrimental changes occur in the arterial wall, which include physiological and biochemical changes. Furthermore, this disease is characterized by...

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Autores principales:	Olufunke Omolola Arishe, Fernanda Priviero, Stephanie A. Wilczynski, R. Clinton Webb
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hypertension exosomes intercellular communication Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0ecb465e03964358b7d387f89d93cbeb
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id	oai:doaj.org-article:0ecb465e03964358b7d387f89d93cbeb
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spelling	oai:doaj.org-article:0ecb465e03964358b7d387f89d93cbeb2021-11-11T17:08:57ZExosomes as Intercellular Messengers in Hypertension10.3390/ijms2221116851422-00671661-6596https://doaj.org/article/0ecb465e03964358b7d387f89d93cbeb2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11685https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067People living with hypertension have a higher risk of developing heart diseases, and hypertension remains a top cause of mortality. In hypertension, some detrimental changes occur in the arterial wall, which include physiological and biochemical changes. Furthermore, this disease is characterized by turbulent blood flow, increased fluid shear stress, remodeling of the blood vessels, and endothelial dysfunction. As a complex disease, hypertension is thought to be caused by an array of factors, its etiology consisting of both environmental and genetic factors. The Mosaic Theory of hypertension states that many factors, including genetics, environment, adaptive, neural, mechanical, and hormonal perturbations are intertwined, leading to increases in blood pressure. Long-term efforts by several investigators have provided invaluable insight into the physiological mechanisms responsible for the pathogenesis of hypertension, and these include increased activity of the sympathetic nervous system, overactivation of the renin–angiotensin–aldosterone system (RAAS), dysfunction of the vascular endothelium, impaired platelet function, thrombogenesis, vascular smooth muscle and cardiac hypertrophy, and altered angiogenesis. Exosomes are extracellular vesicles released by all cells and carry nucleic acids, proteins, lipids, and metabolites into the extracellular environment. They play a role in intercellular communication and are involved in the pathophysiology of diseases. Since the discovery of exosomes in the 1980s, numerous studies have been carried out to understand the biogenesis, composition, and function of exosomes. In this review, we will discuss the role of exosomes as intercellular messengers in hypertension.Olufunke Omolola ArisheFernanda PrivieroStephanie A. WilczynskiR. Clinton WebbMDPI AGarticlehypertensionexosomesintercellular communicationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11685, p 11685 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertension exosomes intercellular communication Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	hypertension exosomes intercellular communication Biology (General) QH301-705.5 Chemistry QD1-999 Olufunke Omolola Arishe Fernanda Priviero Stephanie A. Wilczynski R. Clinton Webb Exosomes as Intercellular Messengers in Hypertension
description	People living with hypertension have a higher risk of developing heart diseases, and hypertension remains a top cause of mortality. In hypertension, some detrimental changes occur in the arterial wall, which include physiological and biochemical changes. Furthermore, this disease is characterized by turbulent blood flow, increased fluid shear stress, remodeling of the blood vessels, and endothelial dysfunction. As a complex disease, hypertension is thought to be caused by an array of factors, its etiology consisting of both environmental and genetic factors. The Mosaic Theory of hypertension states that many factors, including genetics, environment, adaptive, neural, mechanical, and hormonal perturbations are intertwined, leading to increases in blood pressure. Long-term efforts by several investigators have provided invaluable insight into the physiological mechanisms responsible for the pathogenesis of hypertension, and these include increased activity of the sympathetic nervous system, overactivation of the renin–angiotensin–aldosterone system (RAAS), dysfunction of the vascular endothelium, impaired platelet function, thrombogenesis, vascular smooth muscle and cardiac hypertrophy, and altered angiogenesis. Exosomes are extracellular vesicles released by all cells and carry nucleic acids, proteins, lipids, and metabolites into the extracellular environment. They play a role in intercellular communication and are involved in the pathophysiology of diseases. Since the discovery of exosomes in the 1980s, numerous studies have been carried out to understand the biogenesis, composition, and function of exosomes. In this review, we will discuss the role of exosomes as intercellular messengers in hypertension.
format	article
author	Olufunke Omolola Arishe Fernanda Priviero Stephanie A. Wilczynski R. Clinton Webb
author_facet	Olufunke Omolola Arishe Fernanda Priviero Stephanie A. Wilczynski R. Clinton Webb
author_sort	Olufunke Omolola Arishe
title	Exosomes as Intercellular Messengers in Hypertension
title_short	Exosomes as Intercellular Messengers in Hypertension
title_full	Exosomes as Intercellular Messengers in Hypertension
title_fullStr	Exosomes as Intercellular Messengers in Hypertension
title_full_unstemmed	Exosomes as Intercellular Messengers in Hypertension
title_sort	exosomes as intercellular messengers in hypertension
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0ecb465e03964358b7d387f89d93cbeb
work_keys_str_mv	AT olufunkeomololaarishe exosomesasintercellularmessengersinhypertension AT fernandapriviero exosomesasintercellularmessengersinhypertension AT stephanieawilczynski exosomesasintercellularmessengersinhypertension AT rclintonwebb exosomesasintercellularmessengersinhypertension
_version_	1718432161575469056

Exosomes as Intercellular Messengers in Hypertension

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