Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.

<h4>Background</h4>Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the en...

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Autores principales:	Sanne Willems, Daniël van der Velden, Paul H A Quax, Gert Jan de Borst, Jean-Paul P M de Vries, Frans L Moll, Johan Kuiper, René E M Toes, Saskia C A de Jager, Dominique P V de Kleijn, Imo E Hoefer, Gerard Pasterkamp, Ilze Bot
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ed8c556a6bf41fda5b555b8937c1fcd
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spelling	oai:doaj.org-article:0ed8c556a6bf41fda5b555b8937c1fcd2021-11-18T08:31:35ZCirculating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.1932-620310.1371/journal.pone.0088984https://doaj.org/article/0ed8c556a6bf41fda5b555b8937c1fcd2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586471/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activate mast cells during the progression and destabilization of atherosclerotic lesions remain unidentified. Mast cells can be activated by immunoglobulins and in the present study, we aimed to establish whether specific immunoglobulins in plasma of patients scheduled for carotid endarterectomy were related to (activated) intraplaque mast cell numbers and plasma tryptase levels. In addition, the levels were related to other vulnerable plaque characteristics and baseline clinical data.<h4>Methods and results</h4>OxLDL-IgG, total IgG and total IgE levels were measured in 135 patients who underwent carotid endarterectomy. No associations were observed between the tested plasma immunoglobulin levels and total mast cell numbers in atherosclerotic plaques. Furthermore, no associations were found between IgG levels and the following plaque characteristics: lipid core size, degree of calcification, number of macrophages or smooth muscle cells, amount of collagen and number of microvessels. Interestingly, statin use was negatively associated with plasma IgE and oxLDL-IgG levels.<h4>Conclusions</h4>In patients suffering from carotid artery disease, total IgE, total IgG and oxLDL-IgG levels do not associate with plaque mast cell numbers or other vulnerable plaque histopathological characteristics. This study thus does not provide evidence that the immunoglobulins tested in our cohort play a role in intraplaque mast cell activation or grade of atherosclerosis.Sanne WillemsDaniël van der VeldenPaul H A QuaxGert Jan de BorstJean-Paul P M de VriesFrans L MollJohan KuiperRené E M ToesSaskia C A de JagerDominique P V de KleijnImo E HoeferGerard PasterkampIlze BotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88984 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanne Willems Daniël van der Velden Paul H A Quax Gert Jan de Borst Jean-Paul P M de Vries Frans L Moll Johan Kuiper René E M Toes Saskia C A de Jager Dominique P V de Kleijn Imo E Hoefer Gerard Pasterkamp Ilze Bot Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
description	<h4>Background</h4>Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activate mast cells during the progression and destabilization of atherosclerotic lesions remain unidentified. Mast cells can be activated by immunoglobulins and in the present study, we aimed to establish whether specific immunoglobulins in plasma of patients scheduled for carotid endarterectomy were related to (activated) intraplaque mast cell numbers and plasma tryptase levels. In addition, the levels were related to other vulnerable plaque characteristics and baseline clinical data.<h4>Methods and results</h4>OxLDL-IgG, total IgG and total IgE levels were measured in 135 patients who underwent carotid endarterectomy. No associations were observed between the tested plasma immunoglobulin levels and total mast cell numbers in atherosclerotic plaques. Furthermore, no associations were found between IgG levels and the following plaque characteristics: lipid core size, degree of calcification, number of macrophages or smooth muscle cells, amount of collagen and number of microvessels. Interestingly, statin use was negatively associated with plasma IgE and oxLDL-IgG levels.<h4>Conclusions</h4>In patients suffering from carotid artery disease, total IgE, total IgG and oxLDL-IgG levels do not associate with plaque mast cell numbers or other vulnerable plaque histopathological characteristics. This study thus does not provide evidence that the immunoglobulins tested in our cohort play a role in intraplaque mast cell activation or grade of atherosclerosis.
format	article
author	Sanne Willems Daniël van der Velden Paul H A Quax Gert Jan de Borst Jean-Paul P M de Vries Frans L Moll Johan Kuiper René E M Toes Saskia C A de Jager Dominique P V de Kleijn Imo E Hoefer Gerard Pasterkamp Ilze Bot
author_facet	Sanne Willems Daniël van der Velden Paul H A Quax Gert Jan de Borst Jean-Paul P M de Vries Frans L Moll Johan Kuiper René E M Toes Saskia C A de Jager Dominique P V de Kleijn Imo E Hoefer Gerard Pasterkamp Ilze Bot
author_sort	Sanne Willems
title	Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
title_short	Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
title_full	Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
title_fullStr	Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
title_full_unstemmed	Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
title_sort	circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0ed8c556a6bf41fda5b555b8937c1fcd
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Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis.

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