Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

Mario F Mendez1–3 1Department of Neurology, 2Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; 3Neurology Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Abstr...

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Autor principal:	Mendez MF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Frontotemporal dementia mania bipolar disorder progranulin mutation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0ede604086374514925b4ce5b0ef510b
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spelling	oai:doaj.org-article:0ede604086374514925b4ce5b0ef510b2021-12-02T05:19:57ZManic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation1178-2021https://doaj.org/article/0ede604086374514925b4ce5b0ef510b2018-02-01T00:00:00Zhttps://www.dovepress.com/manic-behavior-and-asymmetric-right-frontotemporal-dementia-from-a-nov-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mario F Mendez1–3 1Department of Neurology, 2Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; 3Neurology Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Abstract: Studies suggest a relationship of manic behavior and bipolar disorder (BD) with behavioral variant frontotemporal dementia (bvFTD). The nature of this relationship is unclear. This report presents a patient with initial manic behavior as the main manifestation of familial bvFTD from a novel progranulin (GRN) mutation. In contrast, there are other reports of a long background of BD preceding a diagnosis of bvFTD. A review of the literature and this patient suggest that manic symptoms result from damage to right frontotemporal neural structures from longstanding BD, as well as from bvFTD and other focal neurological disorders. In addition, there is a subgroup of patients with a probable genetic predisposition to both BD and bvFTD. Keywords: frontotemporal dementia, mania, bipolar disorder, progranulin mutationMendez MFDove Medical PressarticleFrontotemporal dementiamaniabipolar disorderprogranulin mutationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 657-662 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Frontotemporal dementia mania bipolar disorder progranulin mutation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Frontotemporal dementia mania bipolar disorder progranulin mutation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Mendez MF Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
description	Mario F Mendez1–3 1Department of Neurology, 2Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA; 3Neurology Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Abstract: Studies suggest a relationship of manic behavior and bipolar disorder (BD) with behavioral variant frontotemporal dementia (bvFTD). The nature of this relationship is unclear. This report presents a patient with initial manic behavior as the main manifestation of familial bvFTD from a novel progranulin (GRN) mutation. In contrast, there are other reports of a long background of BD preceding a diagnosis of bvFTD. A review of the literature and this patient suggest that manic symptoms result from damage to right frontotemporal neural structures from longstanding BD, as well as from bvFTD and other focal neurological disorders. In addition, there is a subgroup of patients with a probable genetic predisposition to both BD and bvFTD. Keywords: frontotemporal dementia, mania, bipolar disorder, progranulin mutation
format	article
author	Mendez MF
author_facet	Mendez MF
author_sort	Mendez MF
title	Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
title_short	Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
title_full	Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
title_fullStr	Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
title_full_unstemmed	Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
title_sort	manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0ede604086374514925b4ce5b0ef510b
work_keys_str_mv	AT mendezmf manicbehaviorandasymmetricrightfrontotemporaldementiafromanovelprogranulinmutation
_version_	1718400454960873472

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

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