Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study

Ya-Jie Yu,1,* Rong-Bin Liang,1,* Qi-Chen Yang,2,* Qian-Min Ge,1 Qiu-Yu Li,1 Biao Li,1 Wen-Qing Shi,1 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China; 2Department of Ophthalmology and Visual Sc...

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Autores principales: Yu YJ, Liang RB, Yang QC, Ge QM, Li QY, Li B, Shi WQ, Shao Y
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Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:0ee20210fe8144d297e40d7e998581b82021-12-02T10:22:26ZAltered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study1178-2021https://doaj.org/article/0ee20210fe8144d297e40d7e998581b82020-08-01T00:00:00Zhttps://www.dovepress.com/altered-spontaneous-brain-activity-patterns-in-patients-after-lasik-su-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ya-Jie Yu,1,* Rong-Bin Liang,1,* Qi-Chen Yang,2,* Qian-Min Ge,1 Qiu-Yu Li,1 Biao Li,1 Wen-Qing Shi,1 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China; 2Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Shao Tel/ Fax +86 791-88692520Email freebee99@163.comObjective: Previous studies demonstrated that myopia could result in alterations of brain activity in specific areas. However, whether the visual function could improve by Lasik surgery, with the brain activity alterations also change, is still unknown. Here, we intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in pre-Lasik (PRL) and post-Lasik (POL) patients.Methods: A total of 15 patients with myopia (nine male and six female) were recruited in our study, who were matched according to age, weight, and height. These patients comprised both the PRL and POL groups, which is self-controlled. The patients all underwent resting-state functional magnetic resonance imaging (MRI), and the spontaneous brain activity changes were recorded by the ALFF technique. The data were recorded and arranged in the receiver operating characteristic (ROC) curve, which presented how intrinsic activities altered in different brain regions. Moreover, by Graphpad prism 8, we can analyze the linear correlation between HADS (Hospital Anxiety and Depression Scale) and ALFF values as well.Results: Differences in ALFF values existed in brain regions between the same patient before and after the Lasik operation. The regions with increased ALFF values after Lasik surgery were the left parahippocampal gyrus, cerebellar vermis, and left posterior cingulate cortex. The regions with decreased ALFF values after Lasik surgery were the left supramarginal gyrus and right trigonometric inferior frontal gyrus.Conclusion: We demonstrated significant fluctuations of ALFF values in specific brain areas between the same patients before and after the Lasik surgery. The altered ALFF values reflected the hyperactivity or hypoactivity of the specific brain areas, which may help predict the recovery level of patients’ vision after Lasik surgery. Furthermore, based on the experimental results that presented significant activity alterations in specific brian regions, patients could be speculated equipped with a better visual function.Keywords: myopia, Lasik, resting-state functional MRI, amplitude of low-frequency fluctuationYu YJLiang RBYang QCGe QMLi QYLi BShi WQShao YDove Medical Pressarticlemyopialasikresting-state functional mriamplitude of low-frequencyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1907-1917 (2020)
institution DOAJ
collection DOAJ
language EN
topic myopia
lasik
resting-state functional mri
amplitude of low-frequency
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle myopia
lasik
resting-state functional mri
amplitude of low-frequency
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Yu YJ
Liang RB
Yang QC
Ge QM
Li QY
Li B
Shi WQ
Shao Y
Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study
description Ya-Jie Yu,1,* Rong-Bin Liang,1,* Qi-Chen Yang,2,* Qian-Min Ge,1 Qiu-Yu Li,1 Biao Li,1 Wen-Qing Shi,1 Yi Shao1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, People’s Republic of China; 2Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong 999077, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Shao Tel/ Fax +86 791-88692520Email freebee99@163.comObjective: Previous studies demonstrated that myopia could result in alterations of brain activity in specific areas. However, whether the visual function could improve by Lasik surgery, with the brain activity alterations also change, is still unknown. Here, we intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in pre-Lasik (PRL) and post-Lasik (POL) patients.Methods: A total of 15 patients with myopia (nine male and six female) were recruited in our study, who were matched according to age, weight, and height. These patients comprised both the PRL and POL groups, which is self-controlled. The patients all underwent resting-state functional magnetic resonance imaging (MRI), and the spontaneous brain activity changes were recorded by the ALFF technique. The data were recorded and arranged in the receiver operating characteristic (ROC) curve, which presented how intrinsic activities altered in different brain regions. Moreover, by Graphpad prism 8, we can analyze the linear correlation between HADS (Hospital Anxiety and Depression Scale) and ALFF values as well.Results: Differences in ALFF values existed in brain regions between the same patient before and after the Lasik operation. The regions with increased ALFF values after Lasik surgery were the left parahippocampal gyrus, cerebellar vermis, and left posterior cingulate cortex. The regions with decreased ALFF values after Lasik surgery were the left supramarginal gyrus and right trigonometric inferior frontal gyrus.Conclusion: We demonstrated significant fluctuations of ALFF values in specific brain areas between the same patients before and after the Lasik surgery. The altered ALFF values reflected the hyperactivity or hypoactivity of the specific brain areas, which may help predict the recovery level of patients’ vision after Lasik surgery. Furthermore, based on the experimental results that presented significant activity alterations in specific brian regions, patients could be speculated equipped with a better visual function.Keywords: myopia, Lasik, resting-state functional MRI, amplitude of low-frequency fluctuation
format article
author Yu YJ
Liang RB
Yang QC
Ge QM
Li QY
Li B
Shi WQ
Shao Y
author_facet Yu YJ
Liang RB
Yang QC
Ge QM
Li QY
Li B
Shi WQ
Shao Y
author_sort Yu YJ
title Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study
title_short Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study
title_full Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study
title_fullStr Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study
title_full_unstemmed Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study
title_sort altered spontaneous brain activity patterns in patients after lasik surgery using amplitude of low-frequency fluctuation: a resting-state functional mri study
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/0ee20210fe8144d297e40d7e998581b8
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