Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.

<h4>Unlabelled</h4>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities. A genome-wide association study (GWAS) identified a novel narcolepsy-related single nucleotide polymorphism (SNP), which is locate...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Taku Miyagawa, Hiromi Kawamura, Mariko Obuchi, Asuka Ikesaki, Akiko Ozaki, Katsushi Tokunaga, Yuichi Inoue, Makoto Honda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ee4590165c64229a9bc03d8c2f3cb40
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ee4590165c64229a9bc03d8c2f3cb40
record_format	dspace
spelling	oai:doaj.org-article:0ee4590165c64229a9bc03d8c2f3cb402021-11-18T08:01:06ZEffects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.1932-620310.1371/journal.pone.0053707https://doaj.org/article/0ee4590165c64229a9bc03d8c2f3cb402013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23349733/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities. A genome-wide association study (GWAS) identified a novel narcolepsy-related single nucleotide polymorphism (SNP), which is located adjacent to the carnitine palmitoyltransferase 1B (CPT1B) gene encoding an enzyme involved in β-oxidation of long-chain fatty acids. The mRNA expression levels of CPT1B were associated with this SNP. In addition, we recently reported that acylcarnitine levels were abnormally low in narcolepsy patients. To assess the efficacy of oral L-carnitine for the treatment of narcolepsy, we performed a clinical trial administering L-carnitine (510 mg/day) to patients with the disease. The study design was a randomized, double-blind, cross-over and placebo-controlled trial. Thirty narcolepsy patients were enrolled in our study. Two patients were withdrawn and 28 patients were included in the statistical analysis (15 males and 13 females, all with HLA-DQB1*06:02). L-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. L-carnitine efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration. Differences in the Japanese version of the Epworth Sleepiness Scale (ESS) and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) vitality and mental health subscales did not reach statistical significance between L-carnitine and placebo. This study suggests that oral L-carnitine can be effective in reducing excessive daytime sleepiness in narcolepsy patients.<h4>Trial registration</h4>University hospital Medical Information Network (UMIN) UMIN000003760.Taku MiyagawaHiromi KawamuraMariko ObuchiAsuka IkesakiAkiko OzakiKatsushi TokunagaYuichi InoueMakoto HondaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53707 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Taku Miyagawa Hiromi Kawamura Mariko Obuchi Asuka Ikesaki Akiko Ozaki Katsushi Tokunaga Yuichi Inoue Makoto Honda Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
description	<h4>Unlabelled</h4>Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities. A genome-wide association study (GWAS) identified a novel narcolepsy-related single nucleotide polymorphism (SNP), which is located adjacent to the carnitine palmitoyltransferase 1B (CPT1B) gene encoding an enzyme involved in β-oxidation of long-chain fatty acids. The mRNA expression levels of CPT1B were associated with this SNP. In addition, we recently reported that acylcarnitine levels were abnormally low in narcolepsy patients. To assess the efficacy of oral L-carnitine for the treatment of narcolepsy, we performed a clinical trial administering L-carnitine (510 mg/day) to patients with the disease. The study design was a randomized, double-blind, cross-over and placebo-controlled trial. Thirty narcolepsy patients were enrolled in our study. Two patients were withdrawn and 28 patients were included in the statistical analysis (15 males and 13 females, all with HLA-DQB1*06:02). L-carnitine treatment significantly improved the total time for dozing off during the daytime, calculated from the sleep logs, compared with that of placebo-treated periods. L-carnitine efficiently increased serum acylcarnitine levels, and reduced serum triglycerides concentration. Differences in the Japanese version of the Epworth Sleepiness Scale (ESS) and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) vitality and mental health subscales did not reach statistical significance between L-carnitine and placebo. This study suggests that oral L-carnitine can be effective in reducing excessive daytime sleepiness in narcolepsy patients.<h4>Trial registration</h4>University hospital Medical Information Network (UMIN) UMIN000003760.
format	article
author	Taku Miyagawa Hiromi Kawamura Mariko Obuchi Asuka Ikesaki Akiko Ozaki Katsushi Tokunaga Yuichi Inoue Makoto Honda
author_facet	Taku Miyagawa Hiromi Kawamura Mariko Obuchi Asuka Ikesaki Akiko Ozaki Katsushi Tokunaga Yuichi Inoue Makoto Honda
author_sort	Taku Miyagawa
title	Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
title_short	Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
title_full	Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
title_fullStr	Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
title_full_unstemmed	Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
title_sort	effects of oral l-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0ee4590165c64229a9bc03d8c2f3cb40
work_keys_str_mv	AT takumiyagawa effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT hiromikawamura effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT marikoobuchi effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT asukaikesaki effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT akikoozaki effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT katsushitokunaga effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT yuichiinoue effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial AT makotohonda effectsoforallcarnitineadministrationinnarcolepsypatientsarandomizeddoubleblindcrossoverandplacebocontrolledtrial
_version_	1718422588048277504

Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial.

Ejemplares similares