Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association

In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains. Translational research using a One Health approach provides a fundament...

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Autores principales:	Boaz Arzi, Tracy L. Webb, Thomas G. Koch, Susan W. Volk, Dean H. Betts, Ashlee Watts, Laurie Goodrich, Michael S. Kallos, Amir Kol
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	companion animals stem cell naturally occurring One Health clinical trial therapy Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/0ee4d38c900944a58bb75e8aa05dfc52
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spelling	oai:doaj.org-article:0ee4d38c900944a58bb75e8aa05dfc522021-12-01T16:25:54ZCell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association2297-176910.3389/fvets.2021.779109https://doaj.org/article/0ee4d38c900944a58bb75e8aa05dfc522021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.779109/fullhttps://doaj.org/toc/2297-1769In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains. Translational research using a One Health approach provides a fundamental link between basic biomedical research and medical clinical practice, with the goal of developing strategies for curing or preventing disease and ameliorating pain and suffering in companion animals and humans alike. Veterinary clinical trials in client-owned companion animals affected with naturally occurring, spontaneous disease can inform human clinical trials and significantly improve their outcomes. Innovative cell therapies are an area of rapid development that can benefit from non-traditional and clinically relevant animal models of disease. This manuscript outlines cell types and therapeutic applications that are currently being investigated in companion animals that are affected by naturally occurring diseases. We further discuss how such investigations impact translational efforts into the human medical field, including a critical evaluation of their benefits and shortcomings. Here, leaders in the field of veterinary regenerative medicine argue that experience gained through the use of cell therapies in companion animals with naturally occurring diseases represent a unique and under-utilized resource that could serve as a critical bridge between laboratory/preclinical models and successful human clinical trials through a One-Health approach.Boaz ArziBoaz ArziTracy L. WebbThomas G. KochSusan W. VolkDean H. BettsAshlee WattsLaurie GoodrichMichael S. KallosAmir KolAmir KolFrontiers Media S.A.articlecompanion animalsstem cellnaturally occurringOne Healthclinical trialtherapyVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	companion animals stem cell naturally occurring One Health clinical trial therapy Veterinary medicine SF600-1100
spellingShingle	companion animals stem cell naturally occurring One Health clinical trial therapy Veterinary medicine SF600-1100 Boaz Arzi Boaz Arzi Tracy L. Webb Thomas G. Koch Susan W. Volk Dean H. Betts Ashlee Watts Laurie Goodrich Michael S. Kallos Amir Kol Amir Kol Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association
description	In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains. Translational research using a One Health approach provides a fundamental link between basic biomedical research and medical clinical practice, with the goal of developing strategies for curing or preventing disease and ameliorating pain and suffering in companion animals and humans alike. Veterinary clinical trials in client-owned companion animals affected with naturally occurring, spontaneous disease can inform human clinical trials and significantly improve their outcomes. Innovative cell therapies are an area of rapid development that can benefit from non-traditional and clinically relevant animal models of disease. This manuscript outlines cell types and therapeutic applications that are currently being investigated in companion animals that are affected by naturally occurring diseases. We further discuss how such investigations impact translational efforts into the human medical field, including a critical evaluation of their benefits and shortcomings. Here, leaders in the field of veterinary regenerative medicine argue that experience gained through the use of cell therapies in companion animals with naturally occurring diseases represent a unique and under-utilized resource that could serve as a critical bridge between laboratory/preclinical models and successful human clinical trials through a One-Health approach.
format	article
author	Boaz Arzi Boaz Arzi Tracy L. Webb Thomas G. Koch Susan W. Volk Dean H. Betts Ashlee Watts Laurie Goodrich Michael S. Kallos Amir Kol Amir Kol
author_facet	Boaz Arzi Boaz Arzi Tracy L. Webb Thomas G. Koch Susan W. Volk Dean H. Betts Ashlee Watts Laurie Goodrich Michael S. Kallos Amir Kol Amir Kol
author_sort	Boaz Arzi
title	Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association
title_short	Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association
title_full	Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association
title_fullStr	Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association
title_full_unstemmed	Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association
title_sort	cell therapy in veterinary medicine as a proof-of-concept for human therapies: perspectives from the north american veterinary regenerative medicine association
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0ee4d38c900944a58bb75e8aa05dfc52
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Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association

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