Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a signalling network governing organogenesis and use thi...

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Autores principales:	Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ee51be150a74c26a536081300641197
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spelling	oai:doaj.org-article:0ee51be150a74c26a5360813006411972021-12-02T19:02:25ZSingle cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis10.1038/s41467-020-17968-x2041-1723https://doaj.org/article/0ee51be150a74c26a5360813006411972020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17968-xhttps://doaj.org/toc/2041-1723The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a signalling network governing organogenesis and use this to differentiate human pluripotent stem cells.Lu HanPraneet ChaturvediKeishi KishimotoHiroyuki KoikeTalia NasrKentaro IwasawaKirsten GiesbrechtPhillip C. WitcherAlexandra EicherLauren HainesYarim LeeJohn M. ShannonMitsuru MorimotoJames M. WellsTakanori TakebeAaron M. ZornNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lu Han Praneet Chaturvedi Keishi Kishimoto Hiroyuki Koike Talia Nasr Kentaro Iwasawa Kirsten Giesbrecht Phillip C. Witcher Alexandra Eicher Lauren Haines Yarim Lee John M. Shannon Mitsuru Morimoto James M. Wells Takanori Takebe Aaron M. Zorn Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
description	The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a signalling network governing organogenesis and use this to differentiate human pluripotent stem cells.
format	article
author	Lu Han Praneet Chaturvedi Keishi Kishimoto Hiroyuki Koike Talia Nasr Kentaro Iwasawa Kirsten Giesbrecht Phillip C. Witcher Alexandra Eicher Lauren Haines Yarim Lee John M. Shannon Mitsuru Morimoto James M. Wells Takanori Takebe Aaron M. Zorn
author_facet	Lu Han Praneet Chaturvedi Keishi Kishimoto Hiroyuki Koike Talia Nasr Kentaro Iwasawa Kirsten Giesbrecht Phillip C. Witcher Alexandra Eicher Lauren Haines Yarim Lee John M. Shannon Mitsuru Morimoto James M. Wells Takanori Takebe Aaron M. Zorn
author_sort	Lu Han
title	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
title_short	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
title_full	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
title_fullStr	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
title_full_unstemmed	Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
title_sort	single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0ee51be150a74c26a536081300641197
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Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

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