Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer

Background: Altered copper levels have been observed in several cancers, but studies on the relationship between serum copper and early-stage triple-negative breast cancer (TNBC) remain scare. We sought to establish a predictive model incorporating serum copper levels for individualized survival pre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fangfang Duan, Jianpei Li, Jiajia Huang, Xin Hua, Chenge Song, Li Wang, Xiwen Bi, Wen Xia, Zhongyu Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	serum copper level early-stage triple-negative breast cancer prognostic nomograms maximally selected log-rank statistics survival Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0ee6769d6d3a42c4b4dd566364602f4b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ee6769d6d3a42c4b4dd566364602f4b
record_format	dspace
spelling	oai:doaj.org-article:0ee6769d6d3a42c4b4dd566364602f4b2021-12-01T02:44:51ZEstablishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer2296-634X10.3389/fcell.2021.770115https://doaj.org/article/0ee6769d6d3a42c4b4dd566364602f4b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.770115/fullhttps://doaj.org/toc/2296-634XBackground: Altered copper levels have been observed in several cancers, but studies on the relationship between serum copper and early-stage triple-negative breast cancer (TNBC) remain scare. We sought to establish a predictive model incorporating serum copper levels for individualized survival predictions.Methods: We retrospectively analyzed clinicopathological information and baseline peripheric blood samples of patients diagnosed with early-stage TNBC between September 2005 and October 2016 at Sun Yat-sen University Cancer Center. The optimal cut-off point of serum copper level was determined using maximally selected log-rank statistics. Kaplan-Meier curves were used to estimate survival probabilities. Independent prognostic indicators associated with survival were identified using multivariate Cox regression analysis, and subsequently, prognostic nomograms were established to predict individualized disease-free survival (DFS) and overall survival (OS). The nomograms were validated in a separate cohort of 86 patients from the original randomized clinical trial SYSUCC-001 (SYSUCC-001 cohort).Results: 350 patients were eligible in this study, including 264 in the training cohort and 86 in the SYSUCC-001 cohort. An optimal cut-off value of 21.3 μmol/L of serum copper was determined to maximally divide patients into low- and high-copper groups. After a median follow-up of 87.1 months, patients with high copper levels had significantly worse DFS (p = 0.002) and OS (p < 0.001) than those with low copper levels in the training cohort. Multivariate Cox regression analysis revealed that serum copper level was an independent factor for DFS and OS. Further, prognostic models based on serum copper were established for individualized predictions. These models showed excellent discrimination [C-index for DFS: 0.689, 95% confidence interval (CI): 0.621–0.757; C-index for OS: 0.728, 95% CI: 0.654–0.802] and predictive calibration, and were validated in the SYSUCC-001 cohort.Conclusion: Serum copper level is a potential predictive biomarker for patients with early-stage TNBC. Predictive nomograms based on serum copper might be served as a practical tool for individualized prognostication.Fangfang DuanJianpei LiJiajia HuangXin HuaChenge SongLi WangXiwen BiWen XiaZhongyu YuanFrontiers Media S.A.articleserum copper levelearly-stage triple-negative breast cancerprognostic nomogramsmaximally selected log-rank statisticssurvivalBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum copper level early-stage triple-negative breast cancer prognostic nomograms maximally selected log-rank statistics survival Biology (General) QH301-705.5
spellingShingle	serum copper level early-stage triple-negative breast cancer prognostic nomograms maximally selected log-rank statistics survival Biology (General) QH301-705.5 Fangfang Duan Jianpei Li Jiajia Huang Xin Hua Chenge Song Li Wang Xiwen Bi Wen Xia Zhongyu Yuan Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
description	Background: Altered copper levels have been observed in several cancers, but studies on the relationship between serum copper and early-stage triple-negative breast cancer (TNBC) remain scare. We sought to establish a predictive model incorporating serum copper levels for individualized survival predictions.Methods: We retrospectively analyzed clinicopathological information and baseline peripheric blood samples of patients diagnosed with early-stage TNBC between September 2005 and October 2016 at Sun Yat-sen University Cancer Center. The optimal cut-off point of serum copper level was determined using maximally selected log-rank statistics. Kaplan-Meier curves were used to estimate survival probabilities. Independent prognostic indicators associated with survival were identified using multivariate Cox regression analysis, and subsequently, prognostic nomograms were established to predict individualized disease-free survival (DFS) and overall survival (OS). The nomograms were validated in a separate cohort of 86 patients from the original randomized clinical trial SYSUCC-001 (SYSUCC-001 cohort).Results: 350 patients were eligible in this study, including 264 in the training cohort and 86 in the SYSUCC-001 cohort. An optimal cut-off value of 21.3 μmol/L of serum copper was determined to maximally divide patients into low- and high-copper groups. After a median follow-up of 87.1 months, patients with high copper levels had significantly worse DFS (p = 0.002) and OS (p < 0.001) than those with low copper levels in the training cohort. Multivariate Cox regression analysis revealed that serum copper level was an independent factor for DFS and OS. Further, prognostic models based on serum copper were established for individualized predictions. These models showed excellent discrimination [C-index for DFS: 0.689, 95% confidence interval (CI): 0.621–0.757; C-index for OS: 0.728, 95% CI: 0.654–0.802] and predictive calibration, and were validated in the SYSUCC-001 cohort.Conclusion: Serum copper level is a potential predictive biomarker for patients with early-stage TNBC. Predictive nomograms based on serum copper might be served as a practical tool for individualized prognostication.
format	article
author	Fangfang Duan Jianpei Li Jiajia Huang Xin Hua Chenge Song Li Wang Xiwen Bi Wen Xia Zhongyu Yuan
author_facet	Fangfang Duan Jianpei Li Jiajia Huang Xin Hua Chenge Song Li Wang Xiwen Bi Wen Xia Zhongyu Yuan
author_sort	Fangfang Duan
title	Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
title_short	Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
title_full	Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
title_fullStr	Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
title_full_unstemmed	Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer
title_sort	establishment and validation of prognostic nomograms based on serum copper level for patients with early-stage triple-negative breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0ee6769d6d3a42c4b4dd566364602f4b
work_keys_str_mv	AT fangfangduan establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT jianpeili establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT jiajiahuang establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT xinhua establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT chengesong establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT liwang establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT xiwenbi establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT wenxia establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer AT zhongyuyuan establishmentandvalidationofprognosticnomogramsbasedonserumcopperlevelforpatientswithearlystagetriplenegativebreastcancer
_version_	1718405885594697728

Establishment and Validation of Prognostic Nomograms Based on Serum Copper Level for Patients With Early-Stage Triple-Negative Breast Cancer

Ejemplares similares