ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD
Conventional strategies for cancer treatment are close to their efficiency limits. Meanwhile, rapid development of experimental immunology and immunotherapy led to first successful experiences in antitumor vaccination. Over last decade, remarkable results were obtained by means of anticancer vaccina...
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2017
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oai:doaj.org-article:0ee78b693cbc45f9a7fe896340a2e5882021-11-18T08:03:46ZANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD1563-06252313-741X10.15789/1563-0625-2017-2-145-156https://doaj.org/article/0ee78b693cbc45f9a7fe896340a2e5882017-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1227https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XConventional strategies for cancer treatment are close to their efficiency limits. Meanwhile, rapid development of experimental immunology and immunotherapy led to first successful experiences in antitumor vaccination. Over last decade, remarkable results were obtained by means of anticancer vaccination being implemented into clinical settings thus causing popularity and growth of interest to tumor-specific DNA vaccines. In this review, we discuss basic principles of a DNA vaccine construction, their structural characteristics and diversity, mechanisms of their biological action, pharmaceutical forms and delivery routes into the body.M. V. StegantsevaA. N. MeleshkoSPb RAACIarticleoncologyimmunotherapyantigensvaccineantitumor immunityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 2, Pp 145-156 (2017) |
institution |
DOAJ |
collection |
DOAJ |
language |
RU |
topic |
oncology immunotherapy antigens vaccine antitumor immunity Immunologic diseases. Allergy RC581-607 |
spellingShingle |
oncology immunotherapy antigens vaccine antitumor immunity Immunologic diseases. Allergy RC581-607 M. V. Stegantseva A. N. Meleshko ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD |
description |
Conventional strategies for cancer treatment are close to their efficiency limits. Meanwhile, rapid development of experimental immunology and immunotherapy led to first successful experiences in antitumor vaccination. Over last decade, remarkable results were obtained by means of anticancer vaccination being implemented into clinical settings thus causing popularity and growth of interest to tumor-specific DNA vaccines. In this review, we discuss basic principles of a DNA vaccine construction, their structural characteristics and diversity, mechanisms of their biological action, pharmaceutical forms and delivery routes into the body. |
format |
article |
author |
M. V. Stegantseva A. N. Meleshko |
author_facet |
M. V. Stegantseva A. N. Meleshko |
author_sort |
M. V. Stegantseva |
title |
ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD |
title_short |
ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD |
title_full |
ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD |
title_fullStr |
ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD |
title_full_unstemmed |
ANTICANCER DNA VACCINATION: PRINCIPLE AND PERSPECTIVES OF THE METHOD |
title_sort |
anticancer dna vaccination: principle and perspectives of the method |
publisher |
SPb RAACI |
publishDate |
2017 |
url |
https://doaj.org/article/0ee78b693cbc45f9a7fe896340a2e588 |
work_keys_str_mv |
AT mvstegantseva anticancerdnavaccinationprincipleandperspectivesofthemethod AT anmeleshko anticancerdnavaccinationprincipleandperspectivesofthemethod |
_version_ |
1718422395966980096 |