Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients

Abstract For primary biliary cholangitis (PBC), a sex ratio was reported to be significantly lower than previously cited in the West; we sought to evaluate sex ratio and long-term outcomes in PBC by studying a PBC cohort at a high-volume hospital from January 2001 to July 2016. A retrospective analy...

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Autores principales:	Xiaoli Fan, Tingting Wang, Yi Shen, Xiaotan Xi, Li Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0eec8978f7ce4998b6ff48c7f2afff00
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spelling	oai:doaj.org-article:0eec8978f7ce4998b6ff48c7f2afff002021-12-02T11:40:34ZUnderestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients10.1038/s41598-017-06807-72045-2322https://doaj.org/article/0eec8978f7ce4998b6ff48c7f2afff002017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06807-7https://doaj.org/toc/2045-2322Abstract For primary biliary cholangitis (PBC), a sex ratio was reported to be significantly lower than previously cited in the West; we sought to evaluate sex ratio and long-term outcomes in PBC by studying a PBC cohort at a high-volume hospital from January 2001 to July 2016. A retrospective analysis including 769 PBC patients was conducted. The gender ratio was 6.1:1. Of the patients, 30.6% had one or more extrahepatic autoimmune (EHA) conditions. The proportion of patients with decompensated PBC at diagnosis increased from 25.0% in period 1 to 47.0% in period 4 (p < 0.05). Of the 420 patients without complications on presentation, the Kaplan-Meier estimate revealed distinct outcomes between non-cirrhotic PBC and cirrhotic PBC, with estimated mean survival times of 145.1 months and 104.5 months, respectively (p < 0.001). According to a subgroup analysis, gender and anti-mitochondrial antibody (AMA) status did not affect long-term prognosis, whereas patients with EHA conditions showed better prognoses. This study reveals evolving trends in male prevalence similar to their Western counterparts. Cirrhotic PBC patients were distinct from those with non-cirrhotic PBC at diagnosis based on difference in long-term outcome.Xiaoli FanTingting WangYi ShenXiaotan XiLi YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoli Fan Tingting Wang Yi Shen Xiaotan Xi Li Yang Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients
description	Abstract For primary biliary cholangitis (PBC), a sex ratio was reported to be significantly lower than previously cited in the West; we sought to evaluate sex ratio and long-term outcomes in PBC by studying a PBC cohort at a high-volume hospital from January 2001 to July 2016. A retrospective analysis including 769 PBC patients was conducted. The gender ratio was 6.1:1. Of the patients, 30.6% had one or more extrahepatic autoimmune (EHA) conditions. The proportion of patients with decompensated PBC at diagnosis increased from 25.0% in period 1 to 47.0% in period 4 (p < 0.05). Of the 420 patients without complications on presentation, the Kaplan-Meier estimate revealed distinct outcomes between non-cirrhotic PBC and cirrhotic PBC, with estimated mean survival times of 145.1 months and 104.5 months, respectively (p < 0.001). According to a subgroup analysis, gender and anti-mitochondrial antibody (AMA) status did not affect long-term prognosis, whereas patients with EHA conditions showed better prognoses. This study reveals evolving trends in male prevalence similar to their Western counterparts. Cirrhotic PBC patients were distinct from those with non-cirrhotic PBC at diagnosis based on difference in long-term outcome.
format	article
author	Xiaoli Fan Tingting Wang Yi Shen Xiaotan Xi Li Yang
author_facet	Xiaoli Fan Tingting Wang Yi Shen Xiaotan Xi Li Yang
author_sort	Xiaoli Fan
title	Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients
title_short	Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients
title_full	Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients
title_fullStr	Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients
title_full_unstemmed	Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients
title_sort	underestimated male prevalence of primary biliary cholangitis in china: results of a 16-yr cohort study involving 769 patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0eec8978f7ce4998b6ff48c7f2afff00
work_keys_str_mv	AT xiaolifan underestimatedmaleprevalenceofprimarybiliarycholangitisinchinaresultsofa16yrcohortstudyinvolving769patients AT tingtingwang underestimatedmaleprevalenceofprimarybiliarycholangitisinchinaresultsofa16yrcohortstudyinvolving769patients AT yishen underestimatedmaleprevalenceofprimarybiliarycholangitisinchinaresultsofa16yrcohortstudyinvolving769patients AT xiaotanxi underestimatedmaleprevalenceofprimarybiliarycholangitisinchinaresultsofa16yrcohortstudyinvolving769patients AT liyang underestimatedmaleprevalenceofprimarybiliarycholangitisinchinaresultsofa16yrcohortstudyinvolving769patients
_version_	1718395562184671232

Underestimated Male Prevalence of Primary Biliary Cholangitis in China: Results of a 16-yr cohort study involving 769 patients

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