Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.

Innate antiviral responses in bronchial epithelial cells (BECs) provide the first line of defense against respiratory viral infection and the effectiveness of this response is critically dependent on the type I interferons (IFNs). However the importance of the antiviral responses in BECs during infl...

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Autores principales:	Alan C-Y Hsu, Kristy Parsons, Ian Barr, Sue Lowther, Deborah Middleton, Philip M Hansbro, Peter A B Wark
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0eef907b001041e69763837f978366c0
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spelling	oai:doaj.org-article:0eef907b001041e69763837f978366c02021-11-18T07:26:13ZCritical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.1932-620310.1371/journal.pone.0032947https://doaj.org/article/0eef907b001041e69763837f978366c02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22396801/?tool=EBIhttps://doaj.org/toc/1932-6203Innate antiviral responses in bronchial epithelial cells (BECs) provide the first line of defense against respiratory viral infection and the effectiveness of this response is critically dependent on the type I interferons (IFNs). However the importance of the antiviral responses in BECs during influenza infection is not well understood. We profiled the innate immune response to infection with H3N2 and H5N1 virus using Calu-3 cells and primary BECs to model proximal airway cells. The susceptibility of BECs to influenza infection was not solely dependent on the sialic acid-bearing glycoprotein, and antiviral responses that occurred after viral endocytosis was more important in limiting viral replication. The early antiviral response and apoptosis correlated with the ability to limit viral replication. Both viruses reduced RIG-I associated antiviral responses and subsequent induction of IFN-β. However it was found that there was constitutive release of IFN-β by BECs and this was critical in inducing late antiviral signaling via type I IFN receptors, and was crucial in limiting viral infection. This study characterizes anti-influenza virus responses in airway epithelial cells and shows that constitutive IFN-β release plays a more important role in initiating protective late IFN-stimulated responses during human influenza infection in bronchial epithelial cells.Alan C-Y HsuKristy ParsonsIan BarrSue LowtherDeborah MiddletonPhilip M HansbroPeter A B WarkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32947 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alan C-Y Hsu Kristy Parsons Ian Barr Sue Lowther Deborah Middleton Philip M Hansbro Peter A B Wark Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.
description	Innate antiviral responses in bronchial epithelial cells (BECs) provide the first line of defense against respiratory viral infection and the effectiveness of this response is critically dependent on the type I interferons (IFNs). However the importance of the antiviral responses in BECs during influenza infection is not well understood. We profiled the innate immune response to infection with H3N2 and H5N1 virus using Calu-3 cells and primary BECs to model proximal airway cells. The susceptibility of BECs to influenza infection was not solely dependent on the sialic acid-bearing glycoprotein, and antiviral responses that occurred after viral endocytosis was more important in limiting viral replication. The early antiviral response and apoptosis correlated with the ability to limit viral replication. Both viruses reduced RIG-I associated antiviral responses and subsequent induction of IFN-β. However it was found that there was constitutive release of IFN-β by BECs and this was critical in inducing late antiviral signaling via type I IFN receptors, and was crucial in limiting viral infection. This study characterizes anti-influenza virus responses in airway epithelial cells and shows that constitutive IFN-β release plays a more important role in initiating protective late IFN-stimulated responses during human influenza infection in bronchial epithelial cells.
format	article
author	Alan C-Y Hsu Kristy Parsons Ian Barr Sue Lowther Deborah Middleton Philip M Hansbro Peter A B Wark
author_facet	Alan C-Y Hsu Kristy Parsons Ian Barr Sue Lowther Deborah Middleton Philip M Hansbro Peter A B Wark
author_sort	Alan C-Y Hsu
title	Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.
title_short	Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.
title_full	Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.
title_fullStr	Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.
title_full_unstemmed	Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.
title_sort	critical role of constitutive type i interferon response in bronchial epithelial cell to influenza infection.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0eef907b001041e69763837f978366c0
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Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection.

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