Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.

<h4>Background</h4>Many epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the...

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Autores principales:	Xian-Tao Zeng, Ming-Li Tu, Dong-Yan Liu, Dong Zheng, Jing Zhang, WeiDong Leng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ef0d5ef17f84b6b89c3e44008e48de8
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spelling	oai:doaj.org-article:0ef0d5ef17f84b6b89c3e44008e48de82021-11-18T08:11:31ZPeriodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.1932-620310.1371/journal.pone.0046508https://doaj.org/article/0ef0d5ef17f84b6b89c3e44008e48de82012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23094025/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Many epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD.<h4>Methods</h4>PubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software.<h4>Results</h4>Fourteen observational studies (one nested case-control, eight case-control, and five cross-sectional) involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48-2.91; P<0.001), with sensitivity analysis showing that the result was robust. Subgroups analyses according to study design, ethnicity, assessment of PD/COPD, and adjusted/unadjusted odds ratios also revealed a significant association. Publication bias was detected.<h4>Conclusions</h4>Based on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.Xian-Tao ZengMing-Li TuDong-Yan LiuDong ZhengJing ZhangWeiDong LengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e46508 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xian-Tao Zeng Ming-Li Tu Dong-Yan Liu Dong Zheng Jing Zhang WeiDong Leng Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
description	<h4>Background</h4>Many epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD.<h4>Methods</h4>PubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software.<h4>Results</h4>Fourteen observational studies (one nested case-control, eight case-control, and five cross-sectional) involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48-2.91; P<0.001), with sensitivity analysis showing that the result was robust. Subgroups analyses according to study design, ethnicity, assessment of PD/COPD, and adjusted/unadjusted odds ratios also revealed a significant association. Publication bias was detected.<h4>Conclusions</h4>Based on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.
format	article
author	Xian-Tao Zeng Ming-Li Tu Dong-Yan Liu Dong Zheng Jing Zhang WeiDong Leng
author_facet	Xian-Tao Zeng Ming-Li Tu Dong-Yan Liu Dong Zheng Jing Zhang WeiDong Leng
author_sort	Xian-Tao Zeng
title	Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
title_short	Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
title_full	Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
title_fullStr	Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
title_full_unstemmed	Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
title_sort	periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0ef0d5ef17f84b6b89c3e44008e48de8
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Periodontal disease and risk of chronic obstructive pulmonary disease: a meta-analysis of observational studies.

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