Lkb1 maintains Treg cell lineage identity

The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune di...

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Autores principales:	Di Wu, Yuechen Luo, Wei Guo, Qing Niu, Ting Xue, Fei Yang, Xiaolei Sun, Song Chen, Yuanyuan Liu, Jingru Liu, Zhina Sun, Chunxiao Zhao, Huifang Huang, Fang Liao, Zhongchao Han, Dongming Zhou, Yongguang Yang, Guogang Xu, Tao Cheng, Xiaoming Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ef92e5f9d09435488a06a64dac0a2a3
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record_format	dspace
spelling	oai:doaj.org-article:0ef92e5f9d09435488a06a64dac0a2a32021-12-02T14:40:56ZLkb1 maintains Treg cell lineage identity10.1038/ncomms158762041-1723https://doaj.org/article/0ef92e5f9d09435488a06a64dac0a2a32017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15876https://doaj.org/toc/2041-1723The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.Di WuYuechen LuoWei GuoQing NiuTing XueFei YangXiaolei SunSong ChenYuanyuan LiuJingru LiuZhina SunChunxiao ZhaoHuifang HuangFang LiaoZhongchao HanDongming ZhouYongguang YangGuogang XuTao ChengXiaoming FengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Di Wu Yuechen Luo Wei Guo Qing Niu Ting Xue Fei Yang Xiaolei Sun Song Chen Yuanyuan Liu Jingru Liu Zhina Sun Chunxiao Zhao Huifang Huang Fang Liao Zhongchao Han Dongming Zhou Yongguang Yang Guogang Xu Tao Cheng Xiaoming Feng Lkb1 maintains Treg cell lineage identity
description	The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.
format	article
author	Di Wu Yuechen Luo Wei Guo Qing Niu Ting Xue Fei Yang Xiaolei Sun Song Chen Yuanyuan Liu Jingru Liu Zhina Sun Chunxiao Zhao Huifang Huang Fang Liao Zhongchao Han Dongming Zhou Yongguang Yang Guogang Xu Tao Cheng Xiaoming Feng
author_facet	Di Wu Yuechen Luo Wei Guo Qing Niu Ting Xue Fei Yang Xiaolei Sun Song Chen Yuanyuan Liu Jingru Liu Zhina Sun Chunxiao Zhao Huifang Huang Fang Liao Zhongchao Han Dongming Zhou Yongguang Yang Guogang Xu Tao Cheng Xiaoming Feng
author_sort	Di Wu
title	Lkb1 maintains Treg cell lineage identity
title_short	Lkb1 maintains Treg cell lineage identity
title_full	Lkb1 maintains Treg cell lineage identity
title_fullStr	Lkb1 maintains Treg cell lineage identity
title_full_unstemmed	Lkb1 maintains Treg cell lineage identity
title_sort	lkb1 maintains treg cell lineage identity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0ef92e5f9d09435488a06a64dac0a2a3
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Lkb1 maintains Treg cell lineage identity

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