Retrospective analysis of treatment modalities in diabetic muscle infarction

Ikenna Onyenemezu,1 Eugenio Capitle Jr1,2 1Department of Medicine, 2Allergy/Immunology Rheumatology Division, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA Background: Diabetic muscle infarction (DMI) is a spontaneous necrosis of skeletal muscle of unknown etiology. The major...

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Autores principales:	Onyenemezu I, Capitle E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/0efc6866a625443190052629f9ca3612
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spelling	oai:doaj.org-article:0efc6866a625443190052629f9ca36122021-12-02T01:23:39ZRetrospective analysis of treatment modalities in diabetic muscle infarction1179-156Xhttps://doaj.org/article/0efc6866a625443190052629f9ca36122014-01-01T00:00:00Zhttp://www.dovepress.com/retrospective-analysis-of-treatment-modalities-in-diabetic-muscle-infa-a15479https://doaj.org/toc/1179-156X Ikenna Onyenemezu,1 Eugenio Capitle Jr1,2 1Department of Medicine, 2Allergy/Immunology Rheumatology Division, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA Background: Diabetic muscle infarction (DMI) is a spontaneous necrosis of skeletal muscle of unknown etiology. The major risk factor is longstanding uncontrolled diabetes mellitus (DM). Optimal treatment for DMI is not known. The purpose of this study was to analyze the outcome of surgical treatment, physiotherapy, and bed rest in DMI. Methods: We searched Medline from its inception to April 2013. We selected cases that provided sufficient data on recovery duration, recurrences, and non-recurrences. Baseline characteristics, including age, sex, microvascular complications, lesion size estimated on magnetic resonance imaging, type of diabetes, and duration of diabetes were assessed. The primary outcome was mean time to recovery from initial treatment and secondary outcomes were mean time to recurrence and recurrence rate. Results: Mean time to recovery was 149 (95% confidence interval [CI] 113–186), 71 (95% CI 47–96), and 43 (95% CI 30–57) days for surgery, physiotherapy and bed rest, respectively. These figures were statistically significant only for surgery versus physiotherapy and surgery versus bed rest (P<0.01). Mean time to recurrence was 30, 107, and 297 days for surgery, physiotherapy, and bed rest, respectively. The recurrence rate was 57%, 44%, and 24% for surgery, physiotherapy, and bed rest, respectively. Conclusion: Our results show a similar outcome for physiotherapy as compared with bed rest. It also confirms nonsurgical treatment as a better therapeutic option compared with surgical treatment. Keywords: therapy, infarction, diabetes, complications, comparisonOnyenemezu ICapitle EDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2014, Iss default, Pp 1-6 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Onyenemezu I Capitle E Retrospective analysis of treatment modalities in diabetic muscle infarction
description	Ikenna Onyenemezu,1 Eugenio Capitle Jr1,2 1Department of Medicine, 2Allergy/Immunology Rheumatology Division, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA Background: Diabetic muscle infarction (DMI) is a spontaneous necrosis of skeletal muscle of unknown etiology. The major risk factor is longstanding uncontrolled diabetes mellitus (DM). Optimal treatment for DMI is not known. The purpose of this study was to analyze the outcome of surgical treatment, physiotherapy, and bed rest in DMI. Methods: We searched Medline from its inception to April 2013. We selected cases that provided sufficient data on recovery duration, recurrences, and non-recurrences. Baseline characteristics, including age, sex, microvascular complications, lesion size estimated on magnetic resonance imaging, type of diabetes, and duration of diabetes were assessed. The primary outcome was mean time to recovery from initial treatment and secondary outcomes were mean time to recurrence and recurrence rate. Results: Mean time to recovery was 149 (95% confidence interval [CI] 113–186), 71 (95% CI 47–96), and 43 (95% CI 30–57) days for surgery, physiotherapy and bed rest, respectively. These figures were statistically significant only for surgery versus physiotherapy and surgery versus bed rest (P<0.01). Mean time to recurrence was 30, 107, and 297 days for surgery, physiotherapy, and bed rest, respectively. The recurrence rate was 57%, 44%, and 24% for surgery, physiotherapy, and bed rest, respectively. Conclusion: Our results show a similar outcome for physiotherapy as compared with bed rest. It also confirms nonsurgical treatment as a better therapeutic option compared with surgical treatment. Keywords: therapy, infarction, diabetes, complications, comparison
format	article
author	Onyenemezu I Capitle E
author_facet	Onyenemezu I Capitle E
author_sort	Onyenemezu I
title	Retrospective analysis of treatment modalities in diabetic muscle infarction
title_short	Retrospective analysis of treatment modalities in diabetic muscle infarction
title_full	Retrospective analysis of treatment modalities in diabetic muscle infarction
title_fullStr	Retrospective analysis of treatment modalities in diabetic muscle infarction
title_full_unstemmed	Retrospective analysis of treatment modalities in diabetic muscle infarction
title_sort	retrospective analysis of treatment modalities in diabetic muscle infarction
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0efc6866a625443190052629f9ca3612
work_keys_str_mv	AT onyenemezui retrospectiveanalysisoftreatmentmodalitiesindiabeticmuscleinfarction AT capitlee retrospectiveanalysisoftreatmentmodalitiesindiabeticmuscleinfarction
_version_	1718403056870096896

Retrospective analysis of treatment modalities in diabetic muscle infarction

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