Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability

Cytosine modifications are important epigenetic markers yet their physical influence on DNA is not well understood. Here, Ngo et al. show that different alterations affect DNA flexibility, suggesting a mechanism where modifications change accessibility of nucleosome bound DNA.

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Autores principales:	Thuy T. M. Ngo, Jejoong Yoo, Qing Dai, Qiucen Zhang, Chuan He, Aleksei Aksimentiev, Taekjip Ha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0efdd629e1b94ac2be9c3b50a9bcee44
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spelling	oai:doaj.org-article:0efdd629e1b94ac2be9c3b50a9bcee442021-12-02T14:39:16ZEffects of cytosine modifications on DNA flexibility and nucleosome mechanical stability10.1038/ncomms108132041-1723https://doaj.org/article/0efdd629e1b94ac2be9c3b50a9bcee442016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10813https://doaj.org/toc/2041-1723Cytosine modifications are important epigenetic markers yet their physical influence on DNA is not well understood. Here, Ngo et al. show that different alterations affect DNA flexibility, suggesting a mechanism where modifications change accessibility of nucleosome bound DNA.Thuy T. M. NgoJejoong YooQing DaiQiucen ZhangChuan HeAleksei AksimentievTaekjip HaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thuy T. M. Ngo Jejoong Yoo Qing Dai Qiucen Zhang Chuan He Aleksei Aksimentiev Taekjip Ha Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
description	Cytosine modifications are important epigenetic markers yet their physical influence on DNA is not well understood. Here, Ngo et al. show that different alterations affect DNA flexibility, suggesting a mechanism where modifications change accessibility of nucleosome bound DNA.
format	article
author	Thuy T. M. Ngo Jejoong Yoo Qing Dai Qiucen Zhang Chuan He Aleksei Aksimentiev Taekjip Ha
author_facet	Thuy T. M. Ngo Jejoong Yoo Qing Dai Qiucen Zhang Chuan He Aleksei Aksimentiev Taekjip Ha
author_sort	Thuy T. M. Ngo
title	Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
title_short	Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
title_full	Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
title_fullStr	Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
title_full_unstemmed	Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability
title_sort	effects of cytosine modifications on dna flexibility and nucleosome mechanical stability
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0efdd629e1b94ac2be9c3b50a9bcee44
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Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability

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