Conformational dynamics of the human serotonin transporter during substrate and drug binding

The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics of human SERT in the absence and presence of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ingvar R. Möller, Marika Slivacka, Anne Kathrine Nielsen, Søren G. F. Rasmussen, Ulrik Gether, Claus J. Loland, Kasper D. Rand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0eff74681cb349509bf0274d56961747
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0eff74681cb349509bf0274d56961747
record_format	dspace
spelling	oai:doaj.org-article:0eff74681cb349509bf0274d569617472021-12-02T15:35:05ZConformational dynamics of the human serotonin transporter during substrate and drug binding10.1038/s41467-019-09675-z2041-1723https://doaj.org/article/0eff74681cb349509bf0274d569617472019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09675-zhttps://doaj.org/toc/2041-1723The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics of human SERT in the absence and presence of known substrates and targeted drugs.Ingvar R. MöllerMarika SlivackaAnne Kathrine NielsenSøren G. F. RasmussenUlrik GetherClaus J. LolandKasper D. RandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ingvar R. Möller Marika Slivacka Anne Kathrine Nielsen Søren G. F. Rasmussen Ulrik Gether Claus J. Loland Kasper D. Rand Conformational dynamics of the human serotonin transporter during substrate and drug binding
description	The serotonin transporter (SERT) is responsible for re-uptake of serotonin into the presynaptic neuron and plays a key role in synaptic transmission. Here, the authors use hydrogen-deuterium exchange mass spectrometry to probe the conformational dynamics of human SERT in the absence and presence of known substrates and targeted drugs.
format	article
author	Ingvar R. Möller Marika Slivacka Anne Kathrine Nielsen Søren G. F. Rasmussen Ulrik Gether Claus J. Loland Kasper D. Rand
author_facet	Ingvar R. Möller Marika Slivacka Anne Kathrine Nielsen Søren G. F. Rasmussen Ulrik Gether Claus J. Loland Kasper D. Rand
author_sort	Ingvar R. Möller
title	Conformational dynamics of the human serotonin transporter during substrate and drug binding
title_short	Conformational dynamics of the human serotonin transporter during substrate and drug binding
title_full	Conformational dynamics of the human serotonin transporter during substrate and drug binding
title_fullStr	Conformational dynamics of the human serotonin transporter during substrate and drug binding
title_full_unstemmed	Conformational dynamics of the human serotonin transporter during substrate and drug binding
title_sort	conformational dynamics of the human serotonin transporter during substrate and drug binding
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0eff74681cb349509bf0274d56961747
work_keys_str_mv	AT ingvarrmoller conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding AT marikaslivacka conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding AT annekathrinenielsen conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding AT sørengfrasmussen conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding AT ulrikgether conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding AT clausjloland conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding AT kasperdrand conformationaldynamicsofthehumanserotonintransporterduringsubstrateanddrugbinding
_version_	1718386639772844032

Conformational dynamics of the human serotonin transporter during substrate and drug binding

Ejemplares similares