Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay

Azadeh Asefnejad1, Mohammad Taghi Khorasani2, Aliasghar Behnamghader3, Babak Farsadzadeh1, Shahin Bonakdar4 1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Iran Polymers and Petrochemical Institute, Tehran, Iran; 3Materials and Energy Resea...

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Autores principales:	Asefnejad A, Khorasani MT, Behnamghader A, Farsadzadeh B, Bonakdar S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0effe3e9eb434dbc951f0599c1c1c3e3
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spelling	oai:doaj.org-article:0effe3e9eb434dbc951f0599c1c1c3e32021-12-02T01:58:49ZManufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay1176-91141178-2013https://doaj.org/article/0effe3e9eb434dbc951f0599c1c1c3e32011-10-01T00:00:00Zhttp://www.dovepress.com/manufacturing-of-biodegradable-polyurethane-scaffolds-based-on-polycap-a8489https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Azadeh Asefnejad1, Mohammad Taghi Khorasani2, Aliasghar Behnamghader3, Babak Farsadzadeh1, Shahin Bonakdar4 1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Iran Polymers and Petrochemical Institute, Tehran, Iran; 3Materials and Energy Research Center, Tehran, Iran; 4National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran Background: Biodegradable polyurethanes have found widespread use in soft tissue engineering due to their suitable mechanical properties and biocompatibility. Methods: In this study, polyurethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and a copolymer of 1,4-butanediol as a chain extender. Polyurethane scaffolds were fabricated by a combination of liquid&ndash;liquid phase separation and salt leaching techniques. The effect of the NCO:OH ratio on porosity content and pore morphology was investigated. Results: Scanning electron micrographs demonstrated that the scaffolds had a regular distribution of interconnected pores, with pore diameters of 50&ndash;300 &micro;m, and porosities of 64%&ndash;83%. It was observed that, by increasing the NCO:OH ratio, the average pore size, compressive strength, and compressive modulus increased. L929 fibroblast and chondrocytes were cultured on the scaffolds, and all samples exhibited suitable cell attachment and growth, with a high level of biocompatibility. Conclusion: These biodegradable polyurethane scaffolds demonstrate potential for soft tissue engineering applications. Keywords: polyurethane, tissue engineering, biodegradable, fibroblast cellsAsefnejad AKhorasani MTBehnamghader AFarsadzadeh BBonakdar SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 2375-2384 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Asefnejad A Khorasani MT Behnamghader A Farsadzadeh B Bonakdar S Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
description	Azadeh Asefnejad1, Mohammad Taghi Khorasani2, Aliasghar Behnamghader3, Babak Farsadzadeh1, Shahin Bonakdar4 1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Iran Polymers and Petrochemical Institute, Tehran, Iran; 3Materials and Energy Research Center, Tehran, Iran; 4National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran Background: Biodegradable polyurethanes have found widespread use in soft tissue engineering due to their suitable mechanical properties and biocompatibility. Methods: In this study, polyurethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and a copolymer of 1,4-butanediol as a chain extender. Polyurethane scaffolds were fabricated by a combination of liquid&ndash;liquid phase separation and salt leaching techniques. The effect of the NCO:OH ratio on porosity content and pore morphology was investigated. Results: Scanning electron micrographs demonstrated that the scaffolds had a regular distribution of interconnected pores, with pore diameters of 50&ndash;300 &micro;m, and porosities of 64%&ndash;83%. It was observed that, by increasing the NCO:OH ratio, the average pore size, compressive strength, and compressive modulus increased. L929 fibroblast and chondrocytes were cultured on the scaffolds, and all samples exhibited suitable cell attachment and growth, with a high level of biocompatibility. Conclusion: These biodegradable polyurethane scaffolds demonstrate potential for soft tissue engineering applications. Keywords: polyurethane, tissue engineering, biodegradable, fibroblast cells
format	article
author	Asefnejad A Khorasani MT Behnamghader A Farsadzadeh B Bonakdar S
author_facet	Asefnejad A Khorasani MT Behnamghader A Farsadzadeh B Bonakdar S
author_sort	Asefnejad A
title	Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
title_short	Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
title_full	Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
title_fullStr	Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
title_full_unstemmed	Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
title_sort	manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/0effe3e9eb434dbc951f0599c1c1c3e3
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Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay

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