Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site

ABSTRACT Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are genetically highly variable and have diversified into multiple phylogenetic clades over the past decade. Antigenic drift is a well-studied phenomenon for seasonal human influenza viruses, but much less is known about t...

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Autores principales:	Björn F. Koel, Stefan van der Vliet, David F. Burke, Theo M. Bestebroer, Eny E. Bharoto, I. Wayan W. Yasa, Inna Herliana, Brigitta M. Laksono, Kemin Xu, Eugene Skepner, Colin A. Russell, Guus F. Rimmelzwaan, Daniel R. Perez, Albert D. M. E. Osterhaus, Derek J. Smith, Teguh Y. Prajitno, Ron A. M. Fouchier
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0f04013622194b4b9171bb12343afa88
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Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site

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