Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children’s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is ev...

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Autor principal:	Parco S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	leptin myeloperoxidase insuline resistance Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0f0b86543ab444249f1fad7d023e35c7
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spelling	oai:doaj.org-article:0f0b86543ab444249f1fad7d023e35c72021-12-02T06:39:52ZLeukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?1178-7007https://doaj.org/article/0f0b86543ab444249f1fad7d023e35c72010-05-01T00:00:00Zhttps://www.dovepress.com/leukocyte-peroxidase-and-leptin-an-associated-link-of-glycemic-toleran-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children’s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis, and intraleukocyte myeloperoxidase (MPO), a hemoprotein with a molecular weight of 140 kDa, expression of the inflammatory system, in asthmatic children. Glycemic tolerance is an important pathogenetic element in developing type 2 mellitus diabetes and a confirmed predictor of incident asthma-like symptoms in adults. This work is aimed at assessing a possible correlation between basal leukocyte myeloperoxidase levels, basal leptin and insulin-glycemic tolerance in obese children. Thirty obese children aged between 7 and 15 years were examined. The analyzed data showed a normal response to the insulinemic stimulus in children of both sexes whose basal leptin and MPO values, expressed as MPO intracellular index, werewithin the normal range.Keywords: leptin, myeloperoxidase, glycemic tolerance, asthmaParco SDove Medical Pressarticleleptinmyeloperoxidaseinsuline resistanceSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 113-116 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	leptin myeloperoxidase insuline resistance Specialties of internal medicine RC581-951
spellingShingle	leptin myeloperoxidase insuline resistance Specialties of internal medicine RC581-951 Parco S Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
description	Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children’s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis, and intraleukocyte myeloperoxidase (MPO), a hemoprotein with a molecular weight of 140 kDa, expression of the inflammatory system, in asthmatic children. Glycemic tolerance is an important pathogenetic element in developing type 2 mellitus diabetes and a confirmed predictor of incident asthma-like symptoms in adults. This work is aimed at assessing a possible correlation between basal leukocyte myeloperoxidase levels, basal leptin and insulin-glycemic tolerance in obese children. Thirty obese children aged between 7 and 15 years were examined. The analyzed data showed a normal response to the insulinemic stimulus in children of both sexes whose basal leptin and MPO values, expressed as MPO intracellular index, werewithin the normal range.Keywords: leptin, myeloperoxidase, glycemic tolerance, asthma
format	article
author	Parco S
author_facet	Parco S
author_sort	Parco S
title	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_short	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_full	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_fullStr	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_full_unstemmed	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_sort	leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0f0b86543ab444249f1fad7d023e35c7
work_keys_str_mv	AT parcos leukocyteperoxidaseandleptinanassociatedlinkofglycemictoleranceandbronchialasthma
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Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

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