MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2adeletion.
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Nature Portfolio
2017
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oai:doaj.org-article:0f0c33aaa830403a92bded52b464aea52021-12-02T15:38:56ZMYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma10.1038/ncomms157702041-1723https://doaj.org/article/0f0c33aaa830403a92bded52b464aea52017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15770https://doaj.org/toc/2041-1723Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2adeletion.Sean T. BaileyAleisha M. SmithJordan KardosSara E. WobkerHarper L. WilsonBhavani KrishnanRyoichi SaitoHyo Jin LeeJing ZhangSamuel C. EatonLindsay A. WilliamsUjjawal ManochaDorien J. PetersXinchao PanThomas J. CarrollDean W. FelsherVonn WalterQing ZhangJoel S. ParkerJen Jen YehRichard A. MoffittJanet Y. LeungWilliam Y. KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sean T. Bailey Aleisha M. Smith Jordan Kardos Sara E. Wobker Harper L. Wilson Bhavani Krishnan Ryoichi Saito Hyo Jin Lee Jing Zhang Samuel C. Eaton Lindsay A. Williams Ujjawal Manocha Dorien J. Peters Xinchao Pan Thomas J. Carroll Dean W. Felsher Vonn Walter Qing Zhang Joel S. Parker Jen Jen Yeh Richard A. Moffitt Janet Y. Leung William Y. Kim MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma |
| description |
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2adeletion. |
| format |
article |
| author |
Sean T. Bailey Aleisha M. Smith Jordan Kardos Sara E. Wobker Harper L. Wilson Bhavani Krishnan Ryoichi Saito Hyo Jin Lee Jing Zhang Samuel C. Eaton Lindsay A. Williams Ujjawal Manocha Dorien J. Peters Xinchao Pan Thomas J. Carroll Dean W. Felsher Vonn Walter Qing Zhang Joel S. Parker Jen Jen Yeh Richard A. Moffitt Janet Y. Leung William Y. Kim |
| author_facet |
Sean T. Bailey Aleisha M. Smith Jordan Kardos Sara E. Wobker Harper L. Wilson Bhavani Krishnan Ryoichi Saito Hyo Jin Lee Jing Zhang Samuel C. Eaton Lindsay A. Williams Ujjawal Manocha Dorien J. Peters Xinchao Pan Thomas J. Carroll Dean W. Felsher Vonn Walter Qing Zhang Joel S. Parker Jen Jen Yeh Richard A. Moffitt Janet Y. Leung William Y. Kim |
| author_sort |
Sean T. Bailey |
| title |
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma |
| title_short |
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma |
| title_full |
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma |
| title_fullStr |
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma |
| title_full_unstemmed |
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma |
| title_sort |
myc activation cooperates with vhl and ink4a/arf loss to induce clear cell renal cell carcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0f0c33aaa830403a92bded52b464aea5 |
| work_keys_str_mv |
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