Spatial constraints govern competition of mutant clones in human epidermis

Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to diffe...

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Autores principales: M. D. Lynch, C. N. S. Lynch, E. Craythorne, K. Liakath-Ali, R. Mallipeddi, J. N. Barker, F. M. Watt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0f0d3a09923e4b6eb97e3107824208bf
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Sumario:Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to differential clonal evolution.