Spatial constraints govern competition of mutant clones in human epidermis

Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to diffe...

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Autores principales:	M. D. Lynch, C. N. S. Lynch, E. Craythorne, K. Liakath-Ali, R. Mallipeddi, J. N. Barker, F. M. Watt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f0d3a09923e4b6eb97e3107824208bf
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spelling	oai:doaj.org-article:0f0d3a09923e4b6eb97e3107824208bf2021-12-02T14:40:34ZSpatial constraints govern competition of mutant clones in human epidermis10.1038/s41467-017-00993-82041-1723https://doaj.org/article/0f0d3a09923e4b6eb97e3107824208bf2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00993-8https://doaj.org/toc/2041-1723Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to differential clonal evolution.M. D. LynchC. N. S. LynchE. CraythorneK. Liakath-AliR. MallipeddiJ. N. BarkerF. M. WattNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. D. Lynch C. N. S. Lynch E. Craythorne K. Liakath-Ali R. Mallipeddi J. N. Barker F. M. Watt Spatial constraints govern competition of mutant clones in human epidermis
description	Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation with respect to other mutant clones may lead to differential clonal evolution.
format	article
author	M. D. Lynch C. N. S. Lynch E. Craythorne K. Liakath-Ali R. Mallipeddi J. N. Barker F. M. Watt
author_facet	M. D. Lynch C. N. S. Lynch E. Craythorne K. Liakath-Ali R. Mallipeddi J. N. Barker F. M. Watt
author_sort	M. D. Lynch
title	Spatial constraints govern competition of mutant clones in human epidermis
title_short	Spatial constraints govern competition of mutant clones in human epidermis
title_full	Spatial constraints govern competition of mutant clones in human epidermis
title_fullStr	Spatial constraints govern competition of mutant clones in human epidermis
title_full_unstemmed	Spatial constraints govern competition of mutant clones in human epidermis
title_sort	spatial constraints govern competition of mutant clones in human epidermis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f0d3a09923e4b6eb97e3107824208bf
work_keys_str_mv	AT mdlynch spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis AT cnslynch spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis AT ecraythorne spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis AT kliakathali spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis AT rmallipeddi spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis AT jnbarker spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis AT fmwatt spatialconstraintsgoverncompetitionofmutantclonesinhumanepidermis
_version_	1718390216754987008

Spatial constraints govern competition of mutant clones in human epidermis

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