Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression

Abstract The progression of Alzheimer’s Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functi...

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Autores principales:	Lili Jiang, Danyang Sui, Kaini Qiao, Hao-Ming Dong, Luonan Chen, Ying Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f0ea425dc6a4120865f26130883d21d
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spelling	oai:doaj.org-article:0f0ea425dc6a4120865f26130883d21d2021-12-02T15:08:36ZImpaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression10.1038/s41598-018-19674-72045-2322https://doaj.org/article/0f0ea425dc6a4120865f26130883d21d2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19674-7https://doaj.org/toc/2045-2322Abstract The progression of Alzheimer’s Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.Lili JiangDanyang SuiKaini QiaoHao-Ming DongLuonan ChenYing HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lili Jiang Danyang Sui Kaini Qiao Hao-Ming Dong Luonan Chen Ying Han Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression
description	Abstract The progression of Alzheimer’s Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.
format	article
author	Lili Jiang Danyang Sui Kaini Qiao Hao-Ming Dong Luonan Chen Ying Han
author_facet	Lili Jiang Danyang Sui Kaini Qiao Hao-Ming Dong Luonan Chen Ying Han
author_sort	Lili Jiang
title	Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression
title_short	Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression
title_full	Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression
title_fullStr	Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression
title_full_unstemmed	Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression
title_sort	impaired functional criticality of human brain during alzheimer’s disease progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0f0ea425dc6a4120865f26130883d21d
work_keys_str_mv	AT lilijiang impairedfunctionalcriticalityofhumanbrainduringalzheimersdiseaseprogression AT danyangsui impairedfunctionalcriticalityofhumanbrainduringalzheimersdiseaseprogression AT kainiqiao impairedfunctionalcriticalityofhumanbrainduringalzheimersdiseaseprogression AT haomingdong impairedfunctionalcriticalityofhumanbrainduringalzheimersdiseaseprogression AT luonanchen impairedfunctionalcriticalityofhumanbrainduringalzheimersdiseaseprogression AT yinghan impairedfunctionalcriticalityofhumanbrainduringalzheimersdiseaseprogression
_version_	1718388042510630912

Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression

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