Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

Ash1 is an H3K36 methyltransferase, Trithorax group protein and is critical in antagonizing Polycomb silencing. Here, the authors purify the Drosophila Ash1 complex and identify Mrg15 and Nurf55 as subunits, finding that Mrg15 is recruited by Ash1 and reinforces Ash1 activity.

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Autores principales:	Chang Huang, Fu Yang, Zhuqiang Zhang, Jing Zhang, Gaihong Cai, Lin Li, Yong Zheng, She Chen, Rongwen Xi, Bing Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f12fc739f3640d88d78936cf5ea630f
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spelling	oai:doaj.org-article:0f12fc739f3640d88d78936cf5ea630f2021-12-02T15:38:40ZMrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila10.1038/s41467-017-01897-32041-1723https://doaj.org/article/0f12fc739f3640d88d78936cf5ea630f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01897-3https://doaj.org/toc/2041-1723Ash1 is an H3K36 methyltransferase, Trithorax group protein and is critical in antagonizing Polycomb silencing. Here, the authors purify the Drosophila Ash1 complex and identify Mrg15 and Nurf55 as subunits, finding that Mrg15 is recruited by Ash1 and reinforces Ash1 activity.Chang HuangFu YangZhuqiang ZhangJing ZhangGaihong CaiLin LiYong ZhengShe ChenRongwen XiBing ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang Huang Fu Yang Zhuqiang Zhang Jing Zhang Gaihong Cai Lin Li Yong Zheng She Chen Rongwen Xi Bing Zhu Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila
description	Ash1 is an H3K36 methyltransferase, Trithorax group protein and is critical in antagonizing Polycomb silencing. Here, the authors purify the Drosophila Ash1 complex and identify Mrg15 and Nurf55 as subunits, finding that Mrg15 is recruited by Ash1 and reinforces Ash1 activity.
format	article
author	Chang Huang Fu Yang Zhuqiang Zhang Jing Zhang Gaihong Cai Lin Li Yong Zheng She Chen Rongwen Xi Bing Zhu
author_facet	Chang Huang Fu Yang Zhuqiang Zhang Jing Zhang Gaihong Cai Lin Li Yong Zheng She Chen Rongwen Xi Bing Zhu
author_sort	Chang Huang
title	Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila
title_short	Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila
title_full	Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila
title_fullStr	Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila
title_full_unstemmed	Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila
title_sort	mrg15 stimulates ash1 h3k36 methyltransferase activity and facilitates ash1 trithorax group protein function in drosophila
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f12fc739f3640d88d78936cf5ea630f
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Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila

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