Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study

Abstract This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, cl...

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Autores principales:	Ana Carolina Trevisan, Leonardo Alexandre-Santos, Rodrigo Luppino Assad, Emerson Nobuyuki Itikawa, Felipe Arriva Pitella, Mery Kato, José Henrique Silvah, Antonio Carlos Santos, Paulo Louzada-Junior, Lauro Wichert-Ana
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Systemic lupus erythematosus Neuropsychiatric form Brain SPECT SISCOM Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/0f14c9cc19a24a5482b36e600d395802
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spelling	oai:doaj.org-article:0f14c9cc19a24a5482b36e600d3958022021-11-08T10:58:43ZTemporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study10.1186/s41824-021-00112-32510-3636https://doaj.org/article/0f14c9cc19a24a5482b36e600d3958022021-11-01T00:00:00Zhttps://doi.org/10.1186/s41824-021-00112-3https://doaj.org/toc/2510-3636Abstract This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, clinical and laboratory findings to shed light upon the pathophysiological evolution of the NPSLE. Twenty-six NPSLE patients with MRI and pre- and post-treatment brain SPECT with [99mTc]Tc-ECD. SISCOM features were categorized as improvement, worsening, activation and/or deactivation of rCBF findings. Patients mean age of 43.19 years and 65.38% white were evaluated. The patients mean age at onset of SLE was 26.05 and 42.29 for NPSLE. The mean time between the onset of SLE and first NPSLE symptoms was 05.57 years. The disease has already been initiated as NPSLE in 4 patients. The SLEDAI average score was 31.69 and the SLICC/ACR-DI score was 06.96. The patients underwent an average of 09.23 cyclophosphamide. The SISCOM findings showed functional and pathological states on different brain regions. The rCBF changes were not associated with index scores. There was, however, a trend towards an association between lower SLEDAI scores with improvement and higher SLEDAI with worsening in SISCOM, Also a trend of association between lower SLICC score with improvement, and higher SLICC with worsening. The female gender was predictive of activation and worsening, separately, and deactivation and worsening in a set. Non-white patients were predictive of worsening. The seizure was predictive of deactivation separately, and deactivation and worsening in a set. Finally, normal C3 was a predictor of improvement. The present study showed dynamic brain changes in NPSLE patients. SISCOM technique showed improved rCBF in some brain areas, and worsening, activation and deactivation in others. There were associations between rCBF changes and gender, skin colour and complement C3 and association trends with SLEDAI and SLICC scores.Ana Carolina TrevisanLeonardo Alexandre-SantosRodrigo Luppino AssadEmerson Nobuyuki ItikawaFelipe Arriva PitellaMery KatoJosé Henrique SilvahAntonio Carlos SantosPaulo Louzada-JuniorLauro Wichert-AnaSpringerOpenarticleSystemic lupus erythematosusNeuropsychiatric formBrain SPECTSISCOMMedical physics. Medical radiology. Nuclear medicineR895-920ENEuropean Journal of Hybrid Imaging, Vol 5, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Systemic lupus erythematosus Neuropsychiatric form Brain SPECT SISCOM Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Systemic lupus erythematosus Neuropsychiatric form Brain SPECT SISCOM Medical physics. Medical radiology. Nuclear medicine R895-920 Ana Carolina Trevisan Leonardo Alexandre-Santos Rodrigo Luppino Assad Emerson Nobuyuki Itikawa Felipe Arriva Pitella Mery Kato José Henrique Silvah Antonio Carlos Santos Paulo Louzada-Junior Lauro Wichert-Ana Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
description	Abstract This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, clinical and laboratory findings to shed light upon the pathophysiological evolution of the NPSLE. Twenty-six NPSLE patients with MRI and pre- and post-treatment brain SPECT with [99mTc]Tc-ECD. SISCOM features were categorized as improvement, worsening, activation and/or deactivation of rCBF findings. Patients mean age of 43.19 years and 65.38% white were evaluated. The patients mean age at onset of SLE was 26.05 and 42.29 for NPSLE. The mean time between the onset of SLE and first NPSLE symptoms was 05.57 years. The disease has already been initiated as NPSLE in 4 patients. The SLEDAI average score was 31.69 and the SLICC/ACR-DI score was 06.96. The patients underwent an average of 09.23 cyclophosphamide. The SISCOM findings showed functional and pathological states on different brain regions. The rCBF changes were not associated with index scores. There was, however, a trend towards an association between lower SLEDAI scores with improvement and higher SLEDAI with worsening in SISCOM, Also a trend of association between lower SLICC score with improvement, and higher SLICC with worsening. The female gender was predictive of activation and worsening, separately, and deactivation and worsening in a set. Non-white patients were predictive of worsening. The seizure was predictive of deactivation separately, and deactivation and worsening in a set. Finally, normal C3 was a predictor of improvement. The present study showed dynamic brain changes in NPSLE patients. SISCOM technique showed improved rCBF in some brain areas, and worsening, activation and deactivation in others. There were associations between rCBF changes and gender, skin colour and complement C3 and association trends with SLEDAI and SLICC scores.
format	article
author	Ana Carolina Trevisan Leonardo Alexandre-Santos Rodrigo Luppino Assad Emerson Nobuyuki Itikawa Felipe Arriva Pitella Mery Kato José Henrique Silvah Antonio Carlos Santos Paulo Louzada-Junior Lauro Wichert-Ana
author_facet	Ana Carolina Trevisan Leonardo Alexandre-Santos Rodrigo Luppino Assad Emerson Nobuyuki Itikawa Felipe Arriva Pitella Mery Kato José Henrique Silvah Antonio Carlos Santos Paulo Louzada-Junior Lauro Wichert-Ana
author_sort	Ana Carolina Trevisan
title	Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
title_short	Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
title_full	Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
title_fullStr	Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
title_full_unstemmed	Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
title_sort	temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/0f14c9cc19a24a5482b36e600d395802
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Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study

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