A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma

BackgroundIn newly diagnosed glioblastoma, radiation with concurrent and adjuvant (six cycles) temozolomide (TMZ) is the established standard of postsurgical care. However, the benefit of extending adjuvant TMZ therapy beyond six cycles has remained unknown.MethodsWe searched PubMed, Web of Science,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fahimeh Attarian, Farzad Taghizadeh-Hesary, Azar Fanipakdel, Seyed Alireza Javadinia, Pejman Porouhan, Babak PeyroShabany, Danial Fazilat-Panah
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adjuvant extended chemotherapy glioblastoma temozolomide treatment duration The Stupp protocol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0f17fce4fc254ad2adfc4a8556712e0d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0f17fce4fc254ad2adfc4a8556712e0d
record_format	dspace
spelling	oai:doaj.org-article:0f17fce4fc254ad2adfc4a8556712e0d2021-11-30T14:07:51ZA Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma2234-943X10.3389/fonc.2021.779491https://doaj.org/article/0f17fce4fc254ad2adfc4a8556712e0d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.779491/fullhttps://doaj.org/toc/2234-943XBackgroundIn newly diagnosed glioblastoma, radiation with concurrent and adjuvant (six cycles) temozolomide (TMZ) is the established standard of postsurgical care. However, the benefit of extending adjuvant TMZ therapy beyond six cycles has remained unknown.MethodsWe searched PubMed, Web of Science, Scopus, and Embase up to October 1, 2021. The search keywords were “glioblastoma,” “adjuvant chemotherapy,” and their synonyms. The data of randomized clinical trials were extracted and included in this meta-analysis if they had reported patients’ median overall survival (OS) or median progression-free survival (PFS). The standard and extended chemotherapy regimens were considered as adjuvant TMZ up to six cycles and beyond six cycles (up to a total of 12 cycles), respectively. The median OS and median PFS were pooled and compared.ResultsFour studies consisting of 882 patients (461 patients for the standard chemotherapy group and 421 patients for the extended chemotherapy group) were included in this meta-analysis. The extended TMZ regimen was associated with a nonsignificant improvement in PFS [12.0 months (95% CI 9.0 to 15.0) vs. 10.0 months (95% CI 7.0 to 12.0), P = 0.27] without corresponding improvement in OS [23.0 months (95% CI 19.0 to 27.0) and 24.0 months (95% CI 20.0 to 28.0), P = 0.73].ConclusionsIn newly diagnosed glioblastoma, continuing adjuvant TMZ beyond six cycles did not shown an increase neither in PFS nor OS.Fahimeh AttarianFarzad Taghizadeh-HesaryAzar FanipakdelSeyed Alireza JavadiniaPejman PorouhanBabak PeyroShabanyDanial Fazilat-PanahFrontiers Media S.A.articleadjuvantextended chemotherapyglioblastomatemozolomidetreatment durationThe Stupp protocolNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adjuvant extended chemotherapy glioblastoma temozolomide treatment duration The Stupp protocol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	adjuvant extended chemotherapy glioblastoma temozolomide treatment duration The Stupp protocol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fahimeh Attarian Farzad Taghizadeh-Hesary Azar Fanipakdel Seyed Alireza Javadinia Pejman Porouhan Babak PeyroShabany Danial Fazilat-Panah A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma
description	BackgroundIn newly diagnosed glioblastoma, radiation with concurrent and adjuvant (six cycles) temozolomide (TMZ) is the established standard of postsurgical care. However, the benefit of extending adjuvant TMZ therapy beyond six cycles has remained unknown.MethodsWe searched PubMed, Web of Science, Scopus, and Embase up to October 1, 2021. The search keywords were “glioblastoma,” “adjuvant chemotherapy,” and their synonyms. The data of randomized clinical trials were extracted and included in this meta-analysis if they had reported patients’ median overall survival (OS) or median progression-free survival (PFS). The standard and extended chemotherapy regimens were considered as adjuvant TMZ up to six cycles and beyond six cycles (up to a total of 12 cycles), respectively. The median OS and median PFS were pooled and compared.ResultsFour studies consisting of 882 patients (461 patients for the standard chemotherapy group and 421 patients for the extended chemotherapy group) were included in this meta-analysis. The extended TMZ regimen was associated with a nonsignificant improvement in PFS [12.0 months (95% CI 9.0 to 15.0) vs. 10.0 months (95% CI 7.0 to 12.0), P = 0.27] without corresponding improvement in OS [23.0 months (95% CI 19.0 to 27.0) and 24.0 months (95% CI 20.0 to 28.0), P = 0.73].ConclusionsIn newly diagnosed glioblastoma, continuing adjuvant TMZ beyond six cycles did not shown an increase neither in PFS nor OS.
format	article
author	Fahimeh Attarian Farzad Taghizadeh-Hesary Azar Fanipakdel Seyed Alireza Javadinia Pejman Porouhan Babak PeyroShabany Danial Fazilat-Panah
author_facet	Fahimeh Attarian Farzad Taghizadeh-Hesary Azar Fanipakdel Seyed Alireza Javadinia Pejman Porouhan Babak PeyroShabany Danial Fazilat-Panah
author_sort	Fahimeh Attarian
title	A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma
title_short	A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma
title_full	A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma
title_fullStr	A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma
title_full_unstemmed	A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma
title_sort	systematic review and meta-analysis on the number of adjuvant temozolomide cycles in newly diagnosed glioblastoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0f17fce4fc254ad2adfc4a8556712e0d
work_keys_str_mv	AT fahimehattarian asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT farzadtaghizadehhesary asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT azarfanipakdel asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT seyedalirezajavadinia asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT pejmanporouhan asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT babakpeyroshabany asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT danialfazilatpanah asystematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT fahimehattarian systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT farzadtaghizadehhesary systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT azarfanipakdel systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT seyedalirezajavadinia systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT pejmanporouhan systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT babakpeyroshabany systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma AT danialfazilatpanah systematicreviewandmetaanalysisonthenumberofadjuvanttemozolomidecyclesinnewlydiagnosedglioblastoma
_version_	1718406486934159360

A Systematic Review and Meta-Analysis on the Number of Adjuvant Temozolomide Cycles in Newly Diagnosed Glioblastoma

Ejemplares similares