Progress in genome-wide association studies of schizophrenia in Han Chinese populations

Abstract Since 2006, genome-wide association studies of schizophrenia have led to the identification of numerous novel risk loci for this disease. However, there remains a geographical imbalance in genome-wide association studies, which to date have primarily focused on Western populations. During t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weihua Yue, Xin Yu, Dai Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/0f1d7b4cb3a64612bfa2bd3637d4e52d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0f1d7b4cb3a64612bfa2bd3637d4e52d
record_format	dspace
spelling	oai:doaj.org-article:0f1d7b4cb3a64612bfa2bd3637d4e52d2021-12-02T12:30:09ZProgress in genome-wide association studies of schizophrenia in Han Chinese populations10.1038/s41537-017-0029-12334-265Xhttps://doaj.org/article/0f1d7b4cb3a64612bfa2bd3637d4e52d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41537-017-0029-1https://doaj.org/toc/2334-265XAbstract Since 2006, genome-wide association studies of schizophrenia have led to the identification of numerous novel risk loci for this disease. However, there remains a geographical imbalance in genome-wide association studies, which to date have primarily focused on Western populations. During the last 6 years, genome-wide association studies in Han Chinese populations have identified both the sharing of susceptible loci across ethnicities and genes unique to Han Chinese populations. Here, we review recent progress in genome-wide association studies of schizophrenia in Han Chinese populations. Researchers have identified and replicated the sharing of susceptible genes, such as within the major histocompatibility complex, microRNA 137 (MIR137), zinc finger protein 804A (ZNF804A), vaccinia related kinase 2 (VRK2), and arsenite methyltransferase (AS3MT), across both European and East Asian populations. Several copy number variations identified in European populations have also been validated in the Han Chinese, including duplications at 16p11.2, 15q11.2-13.1, 7q11.23, and VIPR2 and deletions at 22q11.2, 1q21.1-q21.2, and NRXN1. However, these studies have identified some potential confounding factors, such as genetic heterogeneity and the effects of natural selection on tetraspanin 18 (TSPAN18) or zinc finger protein 323 (ZNF323), which may explain the population differences in genome-wide association studies. In the future, genome-wide association studies in Han Chinese populations should include meta-analyzes or mega-analyses with enlarged sample sizes across populations, deep sequencing, precision medicine treatment, and functional exploration of the risk genes for schizophrenia.Weihua YueXin YuDai ZhangNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Weihua Yue Xin Yu Dai Zhang Progress in genome-wide association studies of schizophrenia in Han Chinese populations
description	Abstract Since 2006, genome-wide association studies of schizophrenia have led to the identification of numerous novel risk loci for this disease. However, there remains a geographical imbalance in genome-wide association studies, which to date have primarily focused on Western populations. During the last 6 years, genome-wide association studies in Han Chinese populations have identified both the sharing of susceptible loci across ethnicities and genes unique to Han Chinese populations. Here, we review recent progress in genome-wide association studies of schizophrenia in Han Chinese populations. Researchers have identified and replicated the sharing of susceptible genes, such as within the major histocompatibility complex, microRNA 137 (MIR137), zinc finger protein 804A (ZNF804A), vaccinia related kinase 2 (VRK2), and arsenite methyltransferase (AS3MT), across both European and East Asian populations. Several copy number variations identified in European populations have also been validated in the Han Chinese, including duplications at 16p11.2, 15q11.2-13.1, 7q11.23, and VIPR2 and deletions at 22q11.2, 1q21.1-q21.2, and NRXN1. However, these studies have identified some potential confounding factors, such as genetic heterogeneity and the effects of natural selection on tetraspanin 18 (TSPAN18) or zinc finger protein 323 (ZNF323), which may explain the population differences in genome-wide association studies. In the future, genome-wide association studies in Han Chinese populations should include meta-analyzes or mega-analyses with enlarged sample sizes across populations, deep sequencing, precision medicine treatment, and functional exploration of the risk genes for schizophrenia.
format	article
author	Weihua Yue Xin Yu Dai Zhang
author_facet	Weihua Yue Xin Yu Dai Zhang
author_sort	Weihua Yue
title	Progress in genome-wide association studies of schizophrenia in Han Chinese populations
title_short	Progress in genome-wide association studies of schizophrenia in Han Chinese populations
title_full	Progress in genome-wide association studies of schizophrenia in Han Chinese populations
title_fullStr	Progress in genome-wide association studies of schizophrenia in Han Chinese populations
title_full_unstemmed	Progress in genome-wide association studies of schizophrenia in Han Chinese populations
title_sort	progress in genome-wide association studies of schizophrenia in han chinese populations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f1d7b4cb3a64612bfa2bd3637d4e52d
work_keys_str_mv	AT weihuayue progressingenomewideassociationstudiesofschizophreniainhanchinesepopulations AT xinyu progressingenomewideassociationstudiesofschizophreniainhanchinesepopulations AT daizhang progressingenomewideassociationstudiesofschizophreniainhanchinesepopulations
_version_	1718394379410866176

Progress in genome-wide association studies of schizophrenia in Han Chinese populations

Ejemplares similares