The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

Colistin is an antibiotic used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Here, Jochumsen et al. reconstruct the pathways for the molecular evolution of colistin resistance in P. aeruginosaand show that the number of pathways is highly constrained by interacti...

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Autores principales: Nicholas Jochumsen, Rasmus L. Marvig, Søren Damkiær, Rune Lyngklip Jensen, Wilhelm Paulander, Søren Molin, Lars Jelsbak, Anders Folkesson
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/0f1e3b973d954aa5908a9db2311042aa
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spelling oai:doaj.org-article:0f1e3b973d954aa5908a9db2311042aa2021-12-02T14:39:11ZThe evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions10.1038/ncomms130022041-1723https://doaj.org/article/0f1e3b973d954aa5908a9db2311042aa2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13002https://doaj.org/toc/2041-1723Colistin is an antibiotic used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Here, Jochumsen et al. reconstruct the pathways for the molecular evolution of colistin resistance in P. aeruginosaand show that the number of pathways is highly constrained by interactions among genes.Nicholas JochumsenRasmus L. MarvigSøren DamkiærRune Lyngklip JensenWilhelm PaulanderSøren MolinLars JelsbakAnders FolkessonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nicholas Jochumsen
Rasmus L. Marvig
Søren Damkiær
Rune Lyngklip Jensen
Wilhelm Paulander
Søren Molin
Lars Jelsbak
Anders Folkesson
The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
description Colistin is an antibiotic used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Here, Jochumsen et al. reconstruct the pathways for the molecular evolution of colistin resistance in P. aeruginosaand show that the number of pathways is highly constrained by interactions among genes.
format article
author Nicholas Jochumsen
Rasmus L. Marvig
Søren Damkiær
Rune Lyngklip Jensen
Wilhelm Paulander
Søren Molin
Lars Jelsbak
Anders Folkesson
author_facet Nicholas Jochumsen
Rasmus L. Marvig
Søren Damkiær
Rune Lyngklip Jensen
Wilhelm Paulander
Søren Molin
Lars Jelsbak
Anders Folkesson
author_sort Nicholas Jochumsen
title The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
title_short The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
title_full The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
title_fullStr The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
title_full_unstemmed The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions
title_sort evolution of antimicrobial peptide resistance in pseudomonas aeruginosa is shaped by strong epistatic interactions
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/0f1e3b973d954aa5908a9db2311042aa
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