Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders

Abstract Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current therap...

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Autores principales:	María Laura Palumbo, Alejandro David Moroni, Sofía Quiroga, María Micaela Castro, Adriana Laura Burgueño, Ana María Genaro
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	CNS‐related peptides neurodegeneration protective autoimmunity Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0f1f7b2c9c9f4cc095b1bf1c3dab7e95
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spelling	oai:doaj.org-article:0f1f7b2c9c9f4cc095b1bf1c3dab7e952021-11-16T13:45:54ZImmunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders2052-170710.1002/prp2.795https://doaj.org/article/0f1f7b2c9c9f4cc095b1bf1c3dab7e952021-10-01T00:00:00Zhttps://doi.org/10.1002/prp2.795https://doaj.org/toc/2052-1707Abstract Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current therapeutic strategies only temporarily improve the patients’ quality of life but are insufficient for completely alleviating the symptoms. An interaction between the immune system and the central nervous system (CNS) is widely associated with neuronal damage in NDD. Usually, immune cell infiltration has been identified with inflammation and is considered harmful to the injured CNS. However, the immune system has a crucial role in the protection and regeneration of the injured CNS. Nowadays, there is a consensus that deregulation of immune homeostasis may represent one of the key initial steps in NDD. Dr. Michal Schwartz originally conceived the concept of “protective autoimmunity” (PA) as a well‐controlled peripheral inflammatory reaction after injury, essential for neuroprotection and regeneration. Several studies suggested that immunizing with a weaker version of the neural self‐antigen would generate PA without degenerative autoimmunity. The development of CNS‐related peptides with immunomodulatory neuroprotective effect led to important research to evaluate their use in chronic and acute NDD. In this review, we refer to the role of PA and the potential applications of active immunization as a therapeutic option for NDD treatment. In particular, we focus on the experimental and clinical promissory findings for CNS‐related peptides with beneficial immunomodulatory effects.María Laura PalumboAlejandro David MoroniSofía QuirogaMaría Micaela CastroAdriana Laura BurgueñoAna María GenaroWileyarticleCNS‐related peptidesneurodegenerationprotective autoimmunityTherapeutics. PharmacologyRM1-950ENPharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CNS‐related peptides neurodegeneration protective autoimmunity Therapeutics. Pharmacology RM1-950
spellingShingle	CNS‐related peptides neurodegeneration protective autoimmunity Therapeutics. Pharmacology RM1-950 María Laura Palumbo Alejandro David Moroni Sofía Quiroga María Micaela Castro Adriana Laura Burgueño Ana María Genaro Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
description	Abstract Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current therapeutic strategies only temporarily improve the patients’ quality of life but are insufficient for completely alleviating the symptoms. An interaction between the immune system and the central nervous system (CNS) is widely associated with neuronal damage in NDD. Usually, immune cell infiltration has been identified with inflammation and is considered harmful to the injured CNS. However, the immune system has a crucial role in the protection and regeneration of the injured CNS. Nowadays, there is a consensus that deregulation of immune homeostasis may represent one of the key initial steps in NDD. Dr. Michal Schwartz originally conceived the concept of “protective autoimmunity” (PA) as a well‐controlled peripheral inflammatory reaction after injury, essential for neuroprotection and regeneration. Several studies suggested that immunizing with a weaker version of the neural self‐antigen would generate PA without degenerative autoimmunity. The development of CNS‐related peptides with immunomodulatory neuroprotective effect led to important research to evaluate their use in chronic and acute NDD. In this review, we refer to the role of PA and the potential applications of active immunization as a therapeutic option for NDD treatment. In particular, we focus on the experimental and clinical promissory findings for CNS‐related peptides with beneficial immunomodulatory effects.
format	article
author	María Laura Palumbo Alejandro David Moroni Sofía Quiroga María Micaela Castro Adriana Laura Burgueño Ana María Genaro
author_facet	María Laura Palumbo Alejandro David Moroni Sofía Quiroga María Micaela Castro Adriana Laura Burgueño Ana María Genaro
author_sort	María Laura Palumbo
title	Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
title_short	Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
title_full	Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
title_fullStr	Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
title_full_unstemmed	Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
title_sort	immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/0f1f7b2c9c9f4cc095b1bf1c3dab7e95
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Immunomodulation induced by central nervous system‐related peptides as a therapeutic strategy for neurodegenerative disorders

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