Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in the world, the detection and prognosis of which are still unsatisfactory. Thus, it is essential to explore the factors that may identify ESCC and evaluate the prognosis of ESCC patients. Results: Both pro...

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Autores principales:	Zu-Xuan Chen, Guo-Sheng Li, Li-Hua Yang, He-Chuan Liu, Guang-Mei Qin, Lang Shen, Wei-Ying He, Ting-Qing Gan, Jian-Jun Li
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	esophageal squamous cell carcinoma baculoviral inhibitor of apoptosis repeat containing 5 microarray rna sequencing prognosis Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/0f20ac2ba4384a059d1523f8a078948c
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spelling	oai:doaj.org-article:0f20ac2ba4384a059d1523f8a078948c2021-11-23T01:26:10ZUpregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma10.3934/mbe.20213451551-0018https://doaj.org/article/0f20ac2ba4384a059d1523f8a078948c2021-08-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021345?viewType=HTMLhttps://doaj.org/toc/1551-0018Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in the world, the detection and prognosis of which are still unsatisfactory. Thus, it is essential to explore the factors that may identify ESCC and evaluate the prognosis of ESCC patients. Results: Both protein and mRNA expression levels of BIRC5 are upregulated in ESCC group rather than non-ESCC group (standardized mean difference > 0). BIRC5 mRNA expression is related to the age, tumor location, lymph node stage and clinical stage of ESCC patients (p < 0.05). BIRC5 expression makes it feasible to distinguish ESCC from non-ESCC (area under the curve > 0.9), and its high expression is related to poor prognosis of ESCC patients (restrictive survival time difference = -0.036, p < 0.05). BIRC5 may play an important role in ESCC by influencing the cell cycle pathway, and CDK1, MAD2L and CDC20 may be the hub genes of this pathway. The transcription factors-MAZ and TFPD1 -are likely to regulate the transcription of BIRC5, which may be one of the factors for the high expression of BIRC5 in ESCC. Conclusions: The current study shows that upregulation of BIRC5 may have essential clinical value in ESCC, and contributes to the understanding of the pathogenesis of ESCC.Zu-Xuan ChenGuo-Sheng LiLi-Hua YangHe-Chuan Liu Guang-Mei QinLang ShenWei-Ying HeTing-Qing GanJian-Jun Li AIMS Pressarticleesophageal squamous cell carcinomabaculoviral inhibitor of apoptosis repeat containing 5microarrayrna sequencingprognosisBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 6941-6960 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal squamous cell carcinoma baculoviral inhibitor of apoptosis repeat containing 5 microarray rna sequencing prognosis Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	esophageal squamous cell carcinoma baculoviral inhibitor of apoptosis repeat containing 5 microarray rna sequencing prognosis Biotechnology TP248.13-248.65 Mathematics QA1-939 Zu-Xuan Chen Guo-Sheng Li Li-Hua Yang He-Chuan Liu Guang-Mei Qin Lang Shen Wei-Ying He Ting-Qing Gan Jian-Jun Li Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma
description	Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in the world, the detection and prognosis of which are still unsatisfactory. Thus, it is essential to explore the factors that may identify ESCC and evaluate the prognosis of ESCC patients. Results: Both protein and mRNA expression levels of BIRC5 are upregulated in ESCC group rather than non-ESCC group (standardized mean difference > 0). BIRC5 mRNA expression is related to the age, tumor location, lymph node stage and clinical stage of ESCC patients (p < 0.05). BIRC5 expression makes it feasible to distinguish ESCC from non-ESCC (area under the curve > 0.9), and its high expression is related to poor prognosis of ESCC patients (restrictive survival time difference = -0.036, p < 0.05). BIRC5 may play an important role in ESCC by influencing the cell cycle pathway, and CDK1, MAD2L and CDC20 may be the hub genes of this pathway. The transcription factors-MAZ and TFPD1 -are likely to regulate the transcription of BIRC5, which may be one of the factors for the high expression of BIRC5 in ESCC. Conclusions: The current study shows that upregulation of BIRC5 may have essential clinical value in ESCC, and contributes to the understanding of the pathogenesis of ESCC.
format	article
author	Zu-Xuan Chen Guo-Sheng Li Li-Hua Yang He-Chuan Liu Guang-Mei Qin Lang Shen Wei-Ying He Ting-Qing Gan Jian-Jun Li
author_facet	Zu-Xuan Chen Guo-Sheng Li Li-Hua Yang He-Chuan Liu Guang-Mei Qin Lang Shen Wei-Ying He Ting-Qing Gan Jian-Jun Li
author_sort	Zu-Xuan Chen
title	Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma
title_short	Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma
title_full	Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma
title_fullStr	Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma
title_full_unstemmed	Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma
title_sort	upregulation of birc5 plays essential role in esophageal squamous cell carcinoma
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/0f20ac2ba4384a059d1523f8a078948c
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_version_	1718417361300619264

Upregulation of BIRC5 plays essential role in esophageal squamous cell carcinoma

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