IRF2 is a master regulator of human keratinocyte stem cell fate

Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.

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Autores principales:	Nicolas Mercado, Gabi Schutzius, Christian Kolter, David Estoppey, Sebastian Bergling, Guglielmo Roma, Caroline Gubser Keller, Florian Nigsch, Adrian Salathe, Remi Terranova, John Reece-Hoyes, John Alford, Carsten Russ, Judith Knehr, Dominic Hoepfner, Alexandra Aebi, Heinz Ruffner, Tanner C. Beck, Sajjeev Jagannathan, Calla M. Olson, Hadley E. Sheppard, Selma Z. Elsarrag, Tewis Bouwmeester, Mathias Frederiksen, Felix Lohmann, Charles Y. Lin, Susan Kirkland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f22070deb8646359f9b585b7f128992
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spelling	oai:doaj.org-article:0f22070deb8646359f9b585b7f1289922021-12-02T17:01:40ZIRF2 is a master regulator of human keratinocyte stem cell fate10.1038/s41467-019-12559-x2041-1723https://doaj.org/article/0f22070deb8646359f9b585b7f1289922019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12559-xhttps://doaj.org/toc/2041-1723Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.Nicolas MercadoGabi SchutziusChristian KolterDavid EstoppeySebastian BerglingGuglielmo RomaCaroline Gubser KellerFlorian NigschAdrian SalatheRemi TerranovaJohn Reece-HoyesJohn AlfordCarsten RussJudith KnehrDominic HoepfnerAlexandra AebiHeinz RuffnerTanner C. BeckSajjeev JagannathanCalla M. OlsonHadley E. SheppardSelma Z. ElsarragTewis BouwmeesterMathias FrederiksenFelix LohmannCharles Y. LinSusan KirklandNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Mercado Gabi Schutzius Christian Kolter David Estoppey Sebastian Bergling Guglielmo Roma Caroline Gubser Keller Florian Nigsch Adrian Salathe Remi Terranova John Reece-Hoyes John Alford Carsten Russ Judith Knehr Dominic Hoepfner Alexandra Aebi Heinz Ruffner Tanner C. Beck Sajjeev Jagannathan Calla M. Olson Hadley E. Sheppard Selma Z. Elsarrag Tewis Bouwmeester Mathias Frederiksen Felix Lohmann Charles Y. Lin Susan Kirkland IRF2 is a master regulator of human keratinocyte stem cell fate
description	Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.
format	article
author	Nicolas Mercado Gabi Schutzius Christian Kolter David Estoppey Sebastian Bergling Guglielmo Roma Caroline Gubser Keller Florian Nigsch Adrian Salathe Remi Terranova John Reece-Hoyes John Alford Carsten Russ Judith Knehr Dominic Hoepfner Alexandra Aebi Heinz Ruffner Tanner C. Beck Sajjeev Jagannathan Calla M. Olson Hadley E. Sheppard Selma Z. Elsarrag Tewis Bouwmeester Mathias Frederiksen Felix Lohmann Charles Y. Lin Susan Kirkland
author_facet	Nicolas Mercado Gabi Schutzius Christian Kolter David Estoppey Sebastian Bergling Guglielmo Roma Caroline Gubser Keller Florian Nigsch Adrian Salathe Remi Terranova John Reece-Hoyes John Alford Carsten Russ Judith Knehr Dominic Hoepfner Alexandra Aebi Heinz Ruffner Tanner C. Beck Sajjeev Jagannathan Calla M. Olson Hadley E. Sheppard Selma Z. Elsarrag Tewis Bouwmeester Mathias Frederiksen Felix Lohmann Charles Y. Lin Susan Kirkland
author_sort	Nicolas Mercado
title	IRF2 is a master regulator of human keratinocyte stem cell fate
title_short	IRF2 is a master regulator of human keratinocyte stem cell fate
title_full	IRF2 is a master regulator of human keratinocyte stem cell fate
title_fullStr	IRF2 is a master regulator of human keratinocyte stem cell fate
title_full_unstemmed	IRF2 is a master regulator of human keratinocyte stem cell fate
title_sort	irf2 is a master regulator of human keratinocyte stem cell fate
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0f22070deb8646359f9b585b7f128992
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IRF2 is a master regulator of human keratinocyte stem cell fate

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