Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

Signal-regulatory protein α (SIRPα) is an inhibitory receptor expressed by myeloid cells. Here the authors show that, in preclinical cancer models, resistance to radiotherapy (RT) observed in wild-type mice is overcome in Sirpα-deficient mice, providing evidences that RT-activated Sirpα-deficient ma...

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Autores principales:	Zhen Bian, Lei Shi, Koby Kidder, Ke Zen, Charlie Garnett-Benson, Yuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f23aa06de4e4b218a635173d9341619
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id	oai:doaj.org-article:0f23aa06de4e4b218a635173d9341619
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spelling	oai:doaj.org-article:0f23aa06de4e4b218a635173d93416192021-12-02T15:49:27ZIntratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy10.1038/s41467-021-23442-z2041-1723https://doaj.org/article/0f23aa06de4e4b218a635173d93416192021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23442-zhttps://doaj.org/toc/2041-1723Signal-regulatory protein α (SIRPα) is an inhibitory receptor expressed by myeloid cells. Here the authors show that, in preclinical cancer models, resistance to radiotherapy (RT) observed in wild-type mice is overcome in Sirpα-deficient mice, providing evidences that RT-activated Sirpα-deficient macrophages promote T-cell mediated anti-tumor immune responses.Zhen BianLei ShiKoby KidderKe ZenCharlie Garnett-BensonYuan LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen Bian Lei Shi Koby Kidder Ke Zen Charlie Garnett-Benson Yuan Liu Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
description	Signal-regulatory protein α (SIRPα) is an inhibitory receptor expressed by myeloid cells. Here the authors show that, in preclinical cancer models, resistance to radiotherapy (RT) observed in wild-type mice is overcome in Sirpα-deficient mice, providing evidences that RT-activated Sirpα-deficient macrophages promote T-cell mediated anti-tumor immune responses.
format	article
author	Zhen Bian Lei Shi Koby Kidder Ke Zen Charlie Garnett-Benson Yuan Liu
author_facet	Zhen Bian Lei Shi Koby Kidder Ke Zen Charlie Garnett-Benson Yuan Liu
author_sort	Zhen Bian
title	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
title_short	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
title_full	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
title_fullStr	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
title_full_unstemmed	Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
title_sort	intratumoral sirpα-deficient macrophages activate tumor antigen-specific cytotoxic t cells under radiotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0f23aa06de4e4b218a635173d9341619
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Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy

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