Onkologie und Sport

Introduction: Epidemiologic and controlled clinical studies have shown that exercise training before, during and after a cancer therapy can have a substantial impact on therapy- and cancer-related symptoms. Further research investigated whether the benefits can be extended to cancer progression, rec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Steindorf K, Schmidt ME, Wiskemann J, Ulrich CM
Formato:	article
Lenguaje:	DE EN
Publicado:	Dynamic Media Sales Verlag 2014
Materias:	Sports medicine RC1200-1245
Acceso en línea:	https://doaj.org/article/0f289521dcfc4568ab8063f21be2461f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0f289521dcfc4568ab8063f21be2461f
record_format	dspace
spelling	oai:doaj.org-article:0f289521dcfc4568ab8063f21be2461f2021-11-16T19:01:43ZOnkologie und Sport0344-59252510-526410.5960/dzsm.2014.136https://doaj.org/article/0f289521dcfc4568ab8063f21be2461f2014-11-01T00:00:00Zhttps://www.germanjournalsportsmedicine.com/archive/archive-2014/issue-11/physiologic-and-molecular-mechanisms-linking-endurance-and-resistance-training-with-effects-for-cancer-patients/https://doaj.org/toc/0344-5925https://doaj.org/toc/2510-5264Introduction: Epidemiologic and controlled clinical studies have shown that exercise training before, during and after a cancer therapy can have a substantial impact on therapy- and cancer-related symptoms. Further research investigated whether the benefits can be extended to cancer progression, recurrence, and cancer-specific or overall mortality. The underlying biological mechanisms are presumably complex, and may be specific for different types of training and cancer. Methods: A systematic PubMed-based literature review on the effects of exercise training on biomarkers in adult cancer patients was conducted till November 2013. Results: A total of 25 publications on 6 cancer sites were identified. Different biologic mechanisms on the effects of exercise trainings were discussed. Profound hypotheses included the modulation of metabolic factors, immune function, pro- and anti-inflammatory processes, sex hormones, and DNA repair capacities and oxidative stress. Most studies investigated breast cancer patients, endurance training, and changes in metabolic and inflammatory parameters. Results for all mechanisms are inconsistent. Discussion: Compared to the complexity of the topic and due to the paucity of studies in cancer patients the current level of evidence needs to be classified as preliminary. Future well-powered exercise intervention trials with cancer patients should, if feasible, incorporate translational and hypotheses-driven biomarker research. For clinical practice, these identified limitations of knowledge on mechanisms should not slow the increasing acceptance of physical training as safe, well-tolerated and highly effective supportive cancer therapy.Key Words: Biological mechanisms, exercise training, cancer, clinical studiesSteindorf KSchmidt MEWiskemann JUlrich CMDynamic Media Sales VerlagarticleSports medicineRC1200-1245DEENDeutsche Zeitschrift für Sportmedizin, Vol 65, Iss 11 (2014)
institution	DOAJ
collection	DOAJ
language	DE EN
topic	Sports medicine RC1200-1245
spellingShingle	Sports medicine RC1200-1245 Steindorf K Schmidt ME Wiskemann J Ulrich CM Onkologie und Sport
description	Introduction: Epidemiologic and controlled clinical studies have shown that exercise training before, during and after a cancer therapy can have a substantial impact on therapy- and cancer-related symptoms. Further research investigated whether the benefits can be extended to cancer progression, recurrence, and cancer-specific or overall mortality. The underlying biological mechanisms are presumably complex, and may be specific for different types of training and cancer. Methods: A systematic PubMed-based literature review on the effects of exercise training on biomarkers in adult cancer patients was conducted till November 2013. Results: A total of 25 publications on 6 cancer sites were identified. Different biologic mechanisms on the effects of exercise trainings were discussed. Profound hypotheses included the modulation of metabolic factors, immune function, pro- and anti-inflammatory processes, sex hormones, and DNA repair capacities and oxidative stress. Most studies investigated breast cancer patients, endurance training, and changes in metabolic and inflammatory parameters. Results for all mechanisms are inconsistent. Discussion: Compared to the complexity of the topic and due to the paucity of studies in cancer patients the current level of evidence needs to be classified as preliminary. Future well-powered exercise intervention trials with cancer patients should, if feasible, incorporate translational and hypotheses-driven biomarker research. For clinical practice, these identified limitations of knowledge on mechanisms should not slow the increasing acceptance of physical training as safe, well-tolerated and highly effective supportive cancer therapy.Key Words: Biological mechanisms, exercise training, cancer, clinical studies
format	article
author	Steindorf K Schmidt ME Wiskemann J Ulrich CM
author_facet	Steindorf K Schmidt ME Wiskemann J Ulrich CM
author_sort	Steindorf K
title	Onkologie und Sport
title_short	Onkologie und Sport
title_full	Onkologie und Sport
title_fullStr	Onkologie und Sport
title_full_unstemmed	Onkologie und Sport
title_sort	onkologie und sport
publisher	Dynamic Media Sales Verlag
publishDate	2014
url	https://doaj.org/article/0f289521dcfc4568ab8063f21be2461f
work_keys_str_mv	AT steindorfk onkologieundsport AT schmidtme onkologieundsport AT wiskemannj onkologieundsport AT ulrichcm onkologieundsport
_version_	1718426155705434112

Onkologie und Sport

Ejemplares similares