Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study

Abstract The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand ost...

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Autores principales:	M. Garcia-Gil, C. Reyes, R. Ramos, M. T. Sanchez-Santos, D. Prieto-Alhambra, T. D. Spector, D. J. Hart, N. K. Arden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f2911fd7872435abc35f5260dbca3c1
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spelling	oai:doaj.org-article:0f2911fd7872435abc35f5260dbca3c12021-12-02T15:04:52ZSerum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study10.1038/s41598-017-03317-42045-2322https://doaj.org/article/0f2911fd7872435abc35f5260dbca3c12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03317-4https://doaj.org/toc/2045-2322Abstract The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthritis (RHOA). All women in a prospective population-based cohort from the Chingford study with available baseline lipid measurements and without RHOA on a baseline were included. Study outcome was the incidence of RHOA in year 11 of follow-up. Serum lipid profile variables were analysed as continuous variables and categorised into quartiles. The association between serum lipid profile and RHOA was modeled using multivariable logistic regression. Overall RHOA incidence was 51.6% (45.7–57.4%). An inverse association between HDL cholesterol levels and the incidence of RHOA was observed by quartile: OR of 0.36 [95%CI 0.17–0.75], 0.52 [95%CI 0.26–1.06], and 0.48 [95%CI 0.22–1.03]. Triglycerides levels showed a significant trend. No relationship was found with total or LDL cholesterol. Higher levels of HDL cholesterol appear to protect against RHOA after 11 years of follow-up. More research is needed to elucidate HOA risk factors, the mechanisms related to the lipid pathway, and the effects of lipid-lowering agents on reducing the incidence of OA.M. Garcia-GilC. ReyesR. RamosM. T. Sanchez-SantosD. Prieto-AlhambraT. D. SpectorD. J. HartN. K. ArdenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Garcia-Gil C. Reyes R. Ramos M. T. Sanchez-Santos D. Prieto-Alhambra T. D. Spector D. J. Hart N. K. Arden Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
description	Abstract The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthritis (RHOA). All women in a prospective population-based cohort from the Chingford study with available baseline lipid measurements and without RHOA on a baseline were included. Study outcome was the incidence of RHOA in year 11 of follow-up. Serum lipid profile variables were analysed as continuous variables and categorised into quartiles. The association between serum lipid profile and RHOA was modeled using multivariable logistic regression. Overall RHOA incidence was 51.6% (45.7–57.4%). An inverse association between HDL cholesterol levels and the incidence of RHOA was observed by quartile: OR of 0.36 [95%CI 0.17–0.75], 0.52 [95%CI 0.26–1.06], and 0.48 [95%CI 0.22–1.03]. Triglycerides levels showed a significant trend. No relationship was found with total or LDL cholesterol. Higher levels of HDL cholesterol appear to protect against RHOA after 11 years of follow-up. More research is needed to elucidate HOA risk factors, the mechanisms related to the lipid pathway, and the effects of lipid-lowering agents on reducing the incidence of OA.
format	article
author	M. Garcia-Gil C. Reyes R. Ramos M. T. Sanchez-Santos D. Prieto-Alhambra T. D. Spector D. J. Hart N. K. Arden
author_facet	M. Garcia-Gil C. Reyes R. Ramos M. T. Sanchez-Santos D. Prieto-Alhambra T. D. Spector D. J. Hart N. K. Arden
author_sort	M. Garcia-Gil
title	Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_short	Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_full	Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_fullStr	Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_full_unstemmed	Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_sort	serum lipid levels and risk of hand osteoarthritis: the chingford prospective cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f2911fd7872435abc35f5260dbca3c1
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Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study

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