Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study

Although many neuroimaging studies have reported structural and functional abnormalities in the brains of patients with cognitive impairments following stroke, little is known about the pattern of such brain reorganization in poststroke dementia (PSD). The present study was aimed at investigating al...

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Autores principales:	Huaying Cai, Zhiyong Zhao, Linhui Ni, Guocan Han, Xingyue Hu, Dan Wu, Xianjun Ding, Jin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0f299c7ca14d4af6bd402e67b6281702
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spelling	oai:doaj.org-article:0f299c7ca14d4af6bd402e67b62817022021-11-15T01:19:33ZStructural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study1687-544310.1155/2021/3536234https://doaj.org/article/0f299c7ca14d4af6bd402e67b62817022021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3536234https://doaj.org/toc/1687-5443Although many neuroimaging studies have reported structural and functional abnormalities in the brains of patients with cognitive impairments following stroke, little is known about the pattern of such brain reorganization in poststroke dementia (PSD). The present study was aimed at investigating alterations in spontaneous brain activity and gray matter volume (GMV) in PSD patients. We collected T1-weighted and resting-state functional magnetic resonance imaging data from 20 PSD patients, 24 poststroke nondementia (PSND) patients, and 21 well-matched normal controls (NCs). We compared the differences among the groups in GMV and the fractional amplitude of low-frequency fluctuations (fALFF). Then, we evaluated the relationship between these brain measures and cognitive assessments and explored the possible distinguisher for PSD by receiver operating characteristic (ROC) curve analysis. PSD patients showed smaller GMV in the right superior temporal gyrus and lower fALFF values in the right inferior frontal gyrus than both PSND patients and NCs, but such differences were not observed between PSND patients and NCs. Moreover, GMV in the left medial prefrontal cortex showed a significant positive correlation with the Mini-Cog assessment in PSD patients, and GMV in the left CPL displayed the highest area under the ROC curve among all the features for classifying PSD versus PSND patients. Our findings suggest that PSD patients show dementia-specific structural and functional alteration patterns, which may help elucidate the pathophysiological mechanisms underlying PSD.Huaying CaiZhiyong ZhaoLinhui NiGuocan HanXingyue HuDan WuXianjun DingJin WangHindawi LimitedarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeural Plasticity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Huaying Cai Zhiyong Zhao Linhui Ni Guocan Han Xingyue Hu Dan Wu Xianjun Ding Jin Wang Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study
description	Although many neuroimaging studies have reported structural and functional abnormalities in the brains of patients with cognitive impairments following stroke, little is known about the pattern of such brain reorganization in poststroke dementia (PSD). The present study was aimed at investigating alterations in spontaneous brain activity and gray matter volume (GMV) in PSD patients. We collected T1-weighted and resting-state functional magnetic resonance imaging data from 20 PSD patients, 24 poststroke nondementia (PSND) patients, and 21 well-matched normal controls (NCs). We compared the differences among the groups in GMV and the fractional amplitude of low-frequency fluctuations (fALFF). Then, we evaluated the relationship between these brain measures and cognitive assessments and explored the possible distinguisher for PSD by receiver operating characteristic (ROC) curve analysis. PSD patients showed smaller GMV in the right superior temporal gyrus and lower fALFF values in the right inferior frontal gyrus than both PSND patients and NCs, but such differences were not observed between PSND patients and NCs. Moreover, GMV in the left medial prefrontal cortex showed a significant positive correlation with the Mini-Cog assessment in PSD patients, and GMV in the left CPL displayed the highest area under the ROC curve among all the features for classifying PSD versus PSND patients. Our findings suggest that PSD patients show dementia-specific structural and functional alteration patterns, which may help elucidate the pathophysiological mechanisms underlying PSD.
format	article
author	Huaying Cai Zhiyong Zhao Linhui Ni Guocan Han Xingyue Hu Dan Wu Xianjun Ding Jin Wang
author_facet	Huaying Cai Zhiyong Zhao Linhui Ni Guocan Han Xingyue Hu Dan Wu Xianjun Ding Jin Wang
author_sort	Huaying Cai
title	Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study
title_short	Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study
title_full	Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study
title_fullStr	Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study
title_full_unstemmed	Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study
title_sort	structural and functional deficits in patients with poststroke dementia: a multimodal mri study
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/0f299c7ca14d4af6bd402e67b6281702
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Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study

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