The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible

Abstract There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by...

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Autores principales:	Felice Contaldi, Federico Capuano, Andrea Fulgione, Riccardo Aiese Cigliano, Walter Sanseverino, Domenico Iannelli, Chiara Medaglia, Rosanna Capparelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f2bfa7c363f4194810ee07e1fe11164
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spelling	oai:doaj.org-article:0f2bfa7c363f4194810ee07e1fe111642021-12-02T15:06:14ZThe hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible10.1038/s41598-017-07532-x2045-2322https://doaj.org/article/0f2bfa7c363f4194810ee07e1fe111642017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07532-xhttps://doaj.org/toc/2045-2322Abstract There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases.Felice ContaldiFederico CapuanoAndrea FulgioneRiccardo Aiese CiglianoWalter SanseverinoDomenico IannelliChiara MedagliaRosanna CapparelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Felice Contaldi Federico Capuano Andrea Fulgione Riccardo Aiese Cigliano Walter Sanseverino Domenico Iannelli Chiara Medaglia Rosanna Capparelli The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
description	Abstract There is epidemiological evidence that H. pylori might predispose to Alzheimer’s disease. To understand the cellular processes potentially linking such unrelated events, we incubated the human gastric cells MNK-28 with the H. pylori peptide Hp(2-20). We then monitored the activated genes by global gene expression. The peptide modulated 77 genes, of which 65 are listed in the AlzBase database and include the hallmarks of Alzheimer’s disease: APP, APOE, PSEN1, and PSEN2. A large fraction of modulated genes (30 out of 77) belong to the inflammation pathway. Remarkably, the pathways dis-regulated in Alzheimer’s and Leasch-Nyhan diseases result dis-regulated also in this study. The unsuspected links between such different diseases – though still awaiting formal validation – suggest new directions for the study of neurological diseases.
format	article
author	Felice Contaldi Federico Capuano Andrea Fulgione Riccardo Aiese Cigliano Walter Sanseverino Domenico Iannelli Chiara Medaglia Rosanna Capparelli
author_facet	Felice Contaldi Federico Capuano Andrea Fulgione Riccardo Aiese Cigliano Walter Sanseverino Domenico Iannelli Chiara Medaglia Rosanna Capparelli
author_sort	Felice Contaldi
title	The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
title_short	The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
title_full	The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
title_fullStr	The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
title_full_unstemmed	The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible
title_sort	hypothesis that helicobacter pylori predisposes to alzheimer’s disease is biologically plausible
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f2bfa7c363f4194810ee07e1fe11164
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The hypothesis that Helicobacter pylori predisposes to Alzheimer’s disease is biologically plausible

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