Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells

Hematopoietic stem cells (HSCs) in the bone marrow are quiescent, but are activated in response to stress. Here, the authors show that loss of Med23 leads to greater activation and enhanced myeloid potential of HSCs in response to stress, also Med23 maintains stemness gene expression and suppresses...

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Autores principales:	Xufeng Chen, Jingyao Zhao, Chan Gu, Yu Cui, Yuling Dai, Guangrong Song, Haifeng Liu, Hao Shen, Yuanhua Liu, Yuya Wang, Huayue Xing, Xiaoyan Zhu, Pei Hao, Fan Guo, Xiaolong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f38c24146194335896f6c2d8da8dd39
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spelling	oai:doaj.org-article:0f38c24146194335896f6c2d8da8dd392021-12-02T16:56:39ZMed23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells10.1038/s41467-018-06282-22041-1723https://doaj.org/article/0f38c24146194335896f6c2d8da8dd392018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06282-2https://doaj.org/toc/2041-1723Hematopoietic stem cells (HSCs) in the bone marrow are quiescent, but are activated in response to stress. Here, the authors show that loss of Med23 leads to greater activation and enhanced myeloid potential of HSCs in response to stress, also Med23 maintains stemness gene expression and suppresses myeloid genes.Xufeng ChenJingyao ZhaoChan GuYu CuiYuling DaiGuangrong SongHaifeng LiuHao ShenYuanhua LiuYuya WangHuayue XingXiaoyan ZhuPei HaoFan GuoXiaolong LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xufeng Chen Jingyao Zhao Chan Gu Yu Cui Yuling Dai Guangrong Song Haifeng Liu Hao Shen Yuanhua Liu Yuya Wang Huayue Xing Xiaoyan Zhu Pei Hao Fan Guo Xiaolong Liu Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
description	Hematopoietic stem cells (HSCs) in the bone marrow are quiescent, but are activated in response to stress. Here, the authors show that loss of Med23 leads to greater activation and enhanced myeloid potential of HSCs in response to stress, also Med23 maintains stemness gene expression and suppresses myeloid genes.
format	article
author	Xufeng Chen Jingyao Zhao Chan Gu Yu Cui Yuling Dai Guangrong Song Haifeng Liu Hao Shen Yuanhua Liu Yuya Wang Huayue Xing Xiaoyan Zhu Pei Hao Fan Guo Xiaolong Liu
author_facet	Xufeng Chen Jingyao Zhao Chan Gu Yu Cui Yuling Dai Guangrong Song Haifeng Liu Hao Shen Yuanhua Liu Yuya Wang Huayue Xing Xiaoyan Zhu Pei Hao Fan Guo Xiaolong Liu
author_sort	Xufeng Chen
title	Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
title_short	Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
title_full	Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
title_fullStr	Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
title_full_unstemmed	Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
title_sort	med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0f38c24146194335896f6c2d8da8dd39
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Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells

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