Retinoblastoma: experience of a referral center in the North Region of Portugal

RA da Rocha-Bastos,1 JR Araújo,1 RS Silva,2 MJ Gil-da-Costa,2 E Brandão,1 NJ Farinha,2,3 F Falcão-Reis,1,4 T Dinah-Bragança1 1Department of Ophthalmology, Hospital São João, 2Hematology and Oncology Unit, Pediatric Hospital, Hospita...

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Autores principales:	Rocha-Bastos R, Araújo JR, Silva RS, Gil-da-Costa MJ, Brandão E, Farinha NJ, Falcão-Reis F, Dinah-Bragança T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0f3b9142351d4c7cac886c87901b9047
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spelling	oai:doaj.org-article:0f3b9142351d4c7cac886c87901b90472021-12-02T00:48:40ZRetinoblastoma: experience of a referral center in the North Region of Portugal1177-5483https://doaj.org/article/0f3b9142351d4c7cac886c87901b90472014-05-01T00:00:00Zhttp://www.dovepress.com/retinoblastoma-experience-of-a-referral-center-in-the-north-region-of--a16943https://doaj.org/toc/1177-5483 RA da Rocha-Bastos,1 JR Araújo,1 RS Silva,2 MJ Gil-da-Costa,2 E Brandão,1 NJ Farinha,2,3 F Falcão-Reis,1,4 T Dinah-Bragança1 1Department of Ophthalmology, Hospital São João, 2Hematology and Oncology Unit, Pediatric Hospital, Hospital São João, 3Pediatrics Department, Faculty of Medicine, University of Porto, 4Department of Sense Organs, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To describe the experience of the Ophthalmology Department of Hospital São João (HSJ), a tertiary health care center in North Region, Portugal, in terms of the diagnosis, treatment, and follow-up of retinoblastoma. Methods: This was a retrospective study of patients diagnosed with retinoblastoma in Hospital São João, between 1978 and 2012. Results: Fifty patients with retinoblastoma were evaluated in our institution between 1978 and 2012. Four patients were excluded due to loss of follow-up. Among the 46 retinoblastoma cases, 33 (71.7%) were unilateral and 13 (28.3%) bilateral, with a mean age at diagnosis of 22.19 months and 6.92 months, respectively (P<0.001). Leukocoria was the most common presenting sign (36.9%), followed by strabismus (19.6%), a combination of leukocoria and strabismus (8.7%), and buphthalmia (2.2%). Between 1978 and 1992, nine retinoblastoma cases were referred to our hospital, all of them unilateral, and, in each case, enucleation was performed, with or without salvage therapy. Between 1993 and 2012, 18 eyes with retinoblastoma were successfully managed with conservative treatment. Conclusion: Demographic results were generally coincident with previous reports. It is crucial to screen leukocoria in pediatric practice, even in asymptomatic children. The outcome of retinoblastoma treatment in our hospital is similar to other series in developed countries. Keywords: retinoblastoma, leukocoria, strabismus, enucleation, pediatric cancerRocha-Bastos RAraújo JRSilva RSGil-da-Costa MJBrandão EFarinha NJFalcão-Reis FDinah-Bragança TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 993-997 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Rocha-Bastos R Araújo JR Silva RS Gil-da-Costa MJ Brandão E Farinha NJ Falcão-Reis F Dinah-Bragança T Retinoblastoma: experience of a referral center in the North Region of Portugal
description	RA da Rocha-Bastos,1 JR Araújo,1 RS Silva,2 MJ Gil-da-Costa,2 E Brandão,1 NJ Farinha,2,3 F Falcão-Reis,1,4 T Dinah-Bragança1 1Department of Ophthalmology, Hospital São João, 2Hematology and Oncology Unit, Pediatric Hospital, Hospital São João, 3Pediatrics Department, Faculty of Medicine, University of Porto, 4Department of Sense Organs, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To describe the experience of the Ophthalmology Department of Hospital São João (HSJ), a tertiary health care center in North Region, Portugal, in terms of the diagnosis, treatment, and follow-up of retinoblastoma. Methods: This was a retrospective study of patients diagnosed with retinoblastoma in Hospital São João, between 1978 and 2012. Results: Fifty patients with retinoblastoma were evaluated in our institution between 1978 and 2012. Four patients were excluded due to loss of follow-up. Among the 46 retinoblastoma cases, 33 (71.7%) were unilateral and 13 (28.3%) bilateral, with a mean age at diagnosis of 22.19 months and 6.92 months, respectively (P<0.001). Leukocoria was the most common presenting sign (36.9%), followed by strabismus (19.6%), a combination of leukocoria and strabismus (8.7%), and buphthalmia (2.2%). Between 1978 and 1992, nine retinoblastoma cases were referred to our hospital, all of them unilateral, and, in each case, enucleation was performed, with or without salvage therapy. Between 1993 and 2012, 18 eyes with retinoblastoma were successfully managed with conservative treatment. Conclusion: Demographic results were generally coincident with previous reports. It is crucial to screen leukocoria in pediatric practice, even in asymptomatic children. The outcome of retinoblastoma treatment in our hospital is similar to other series in developed countries. Keywords: retinoblastoma, leukocoria, strabismus, enucleation, pediatric cancer
format	article
author	Rocha-Bastos R Araújo JR Silva RS Gil-da-Costa MJ Brandão E Farinha NJ Falcão-Reis F Dinah-Bragança T
author_facet	Rocha-Bastos R Araújo JR Silva RS Gil-da-Costa MJ Brandão E Farinha NJ Falcão-Reis F Dinah-Bragança T
author_sort	Rocha-Bastos R
title	Retinoblastoma: experience of a referral center in the North Region of Portugal
title_short	Retinoblastoma: experience of a referral center in the North Region of Portugal
title_full	Retinoblastoma: experience of a referral center in the North Region of Portugal
title_fullStr	Retinoblastoma: experience of a referral center in the North Region of Portugal
title_full_unstemmed	Retinoblastoma: experience of a referral center in the North Region of Portugal
title_sort	retinoblastoma: experience of a referral center in the north region of portugal
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0f3b9142351d4c7cac886c87901b9047
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Retinoblastoma: experience of a referral center in the North Region of Portugal

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