Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis

Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be a...

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Autores principales:	Jang Bae Moon, Su Woong Yoo, Changho Lee, Dong-Yeon Kim, Ayoung Pyo, Seong Young Kwon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bone metastasis microenvironment imaging metabolism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0f3bae4c9f9e43168fdb61c7f5d0e77f
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spelling	oai:doaj.org-article:0f3bae4c9f9e43168fdb61c7f5d0e77f2021-11-25T17:08:26ZMultimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis10.3390/cells101128772073-4409https://doaj.org/article/0f3bae4c9f9e43168fdb61c7f5d0e77f2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2877https://doaj.org/toc/2073-4409Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques.Jang Bae MoonSu Woong YooChangho LeeDong-Yeon KimAyoung PyoSeong Young KwonMDPI AGarticlebone metastasismicroenvironmentimagingmetabolismBiology (General)QH301-705.5ENCells, Vol 10, Iss 2877, p 2877 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone metastasis microenvironment imaging metabolism Biology (General) QH301-705.5
spellingShingle	bone metastasis microenvironment imaging metabolism Biology (General) QH301-705.5 Jang Bae Moon Su Woong Yoo Changho Lee Dong-Yeon Kim Ayoung Pyo Seong Young Kwon Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
description	Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques.
format	article
author	Jang Bae Moon Su Woong Yoo Changho Lee Dong-Yeon Kim Ayoung Pyo Seong Young Kwon
author_facet	Jang Bae Moon Su Woong Yoo Changho Lee Dong-Yeon Kim Ayoung Pyo Seong Young Kwon
author_sort	Jang Bae Moon
title	Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_short	Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_full	Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_fullStr	Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_full_unstemmed	Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
title_sort	multimodal imaging-based potential visualization of the tumor microenvironment in bone metastasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0f3bae4c9f9e43168fdb61c7f5d0e77f
work_keys_str_mv	AT jangbaemoon multimodalimagingbasedpotentialvisualizationofthetumormicroenvironmentinbonemetastasis AT suwoongyoo multimodalimagingbasedpotentialvisualizationofthetumormicroenvironmentinbonemetastasis AT changholee multimodalimagingbasedpotentialvisualizationofthetumormicroenvironmentinbonemetastasis AT dongyeonkim multimodalimagingbasedpotentialvisualizationofthetumormicroenvironmentinbonemetastasis AT ayoungpyo multimodalimagingbasedpotentialvisualizationofthetumormicroenvironmentinbonemetastasis AT seongyoungkwon multimodalimagingbasedpotentialvisualizationofthetumormicroenvironmentinbonemetastasis
_version_	1718412694349938688

Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis

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